脂蛋白相关磷脂酶A2与轻型缺血性卒中早期神经功能恶化风险分层的相关性研究

Correlation between lipoprotein associated phospholipase A2 and risk stratification of early neurological deterioration in patients with mild ischemic stroke

目的:研究脂蛋白相关磷脂酶A2(Lp-PLA2)联合改良版ABCD2评分与轻型缺血性卒中早期神经功能恶化(END)的相关性。方法:本研究共收集148例急性轻型缺血性卒中患者为研究对象,应用改良版ABCD2评分进行风险分层,ELISA法检测患者血浆Lp-PLA2水平。结果:END和无END 2组轻型缺血性卒中患者进行比较,END组Lp-PLA2水平显著升高(P<0.05)。Lp-PLA2与改良版ABCD2评分显著相关(P<0.05)。多因素Cox回归分析结果显示ABCD2评分(≥4分)、大动脉狭窄(≥75%)及Lp-PLA2(>200 ng/m L)是轻型脑缺血卒中END复合终点事件的预测因素(P<0.05)。结论:Lp-PLA2联合改良版ABCD2评分可提高轻型缺血性卒中END事件的风险预测能力。

Objective：To explore the correlation between Lp-PLA2 combined with modified ABCD2 score and early neurological deterioration（END） in patients with mild ischemic stroke. Methods：A total of 180 patients with acute mild ischemic stroke were recruited in this study. All patients were evaluated by improved ABCD2 score for risk stratification,and the serum Lp-PLA2 level was detected by ELISA. Results：The level of Lp-PLA2 was significantly increased compared with that in the non END group（P〈0.05）.Lp-PLA2 was significantly related with improved ABCD2 score（P〈0.05）. The Cox regression logistic regression model indicated that ABCD2 score（≥4）,large artery stenosis（≥75%） and Lp-PLA2（〉200 ng/m L） were the predictive factors of END composite end points in mild cerebral ischemic stroke（P〈0. 05）. Conclusion：Lp-PLA2 combined with modified ABCD2 score can improve the ability to predict the risk of END events in mild ischemic stroke.