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TRPV1通道调节血管平滑肌改善高血压作用的研究进展 被引量：2

The Role of TRPV1 in Modulating VSMC Function and Attenuating Hypertension
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摘要 瞬时受体电位香草酸亚型1(transient receptor potential vanilloid 1,TRPV1)通道是一种非选择性阳离子通道,可以被辣椒素、高温等多种刺激因素激活。近年来多项研究表明,TRPV1通道在心血管疾病中发挥重要作用。该文旨在综述现阶段TRPV1通道在调节血管平滑肌细胞(vascular smooth muscle cell,VSMC)功能和降低高血压等相关疾病作用的研究进展。 The transient receptor potential vanilloid type 1 （TRPV1） channel is a non-selective cation channel that can be activated by multiple stimuli, including capsaicin and heat. In recent years, several studies have shown that TRPV1 channels play an important role in cardiovascular diseases. This review focuses on the current knowledge of the role of TRPV1 channel in modulating vascular smooth muscle cell （VSMC） function and attenuating hypertension.
作者 段志莉 吴珺 韩梅 张凡 Duan Zhili Wu Jun Han Mei Zhang Fan(Department of Biochemistry and Molecular Biology, College of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, China)
机构地区 河北医科大学基础医学院生物化学与分子生物学教研室
出处 《中国细胞生物学学报》 CAS CSCD 2016年第8期1020-1024,共5页 Chinese Journal of Cell Biology
基金 国家自然科学基金(批准号:31401199) 河北省自然科学基金(批准号:H2015206427) 河北省教育厅优秀青年基金(批准号:YQ2014030) 中国博士后科学基金第56批面上项目(批准号:2014M560194)资助的课题~~
关键词 TRPV1 高血压 血管平滑肌细胞 神经递质 钙离子 TRPV1 hypertension VSMC neurotransmitters Ca^2＋
分类号 R544.1 [医药卫生—心血管疾病]
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参考文献39

  • 1Su J, Xu HT, Yu JJ, Gao JL, Lei J, Yin QS, et al. Luteolin ameliorates hypertensive vascular remodeling through inhibiting the proliferation and migration of vascular smooth muscle cells. Evid Based Complement Alternat Med 2015; 2014(1): 364876- 90.
  • 2Shang Y, Yoshida T, Amendt BA, Martin JF, Owens GK. Pitx2 is functionally important in the early stages of vascular smooth muscle cell differentiation. J Cell Biol 2008; 181(3): 461-73.
  • 3Schiffrin EL. Vascular remodeling in hypertension mechanisms and treatment. Hypertension 2012; 59(2): 367-74.
  • 4Owens GK, Kumar MS, Wamhoff BR. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev 2004; 84(3): 767-801.
  • 5Yang L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yoshizawa T, et al. Endogenous CGRP protects against neointimal hyperplasia following wire-induced vascular injury. J Mol Cell Cardiol 2013; 59: 55-66.
  • 6Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: A heat-activated ion channel in the pain pathway. Nature 1997; 389(6653): 816-24.
  • 7Qi Y, Qi Z, Li Z, Wong CK, So C, Lo IC, et al. Role of TRPV1 in the differentiation of mouse embryonic stem cells into cardiomyocytes. PLoS One 2015; 10(7): e0133211.
  • 8Ma QP. Expression of capsaicin receptor (VR1) by myelinated primary afferent neurons in rats. Neurosci Lett 2002; 319(2): 87- 90.
  • 9Tominaga M, Caterina MJ, Malmberg AB, Rosen TA, Gilbert H, Skinner K, et al. The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 1998; 21(3): 531-43.
  • 10Pacher P, Batkai S, Kunos G. Cardiovascular pharmacology of cannabinoids. Handb Exp Pharmacol 2005; 53(168): 599-625.

二级参考文献18

  • 1Owens G K, Kumar M S, Wamhoff B R. Molecular regulation of vascular smooth muscle cell differentiation in development and disease [J]. Physiol Rev, 2004, 84(3): 767-801.
  • 2Schiffrin E L. Vascular remodeling in hypertension: mecha- nisms and treatement [ J ]. Hypertension, 2012, 59 ( 2 ) : 367 - 374.
  • 3Zhu Z, Luo Z, Ma S, et al. TRP channels and their implica- tions in metabolic diseases [ J]. Pflugers Arch, 2011, 461 (2) : 211 -223.
  • 4Ma L, Zhong J, Zhao Z, et al. Activation of TRPV1 reduces vascular lipid accumulation and attenuates atherosclerosis [J]. Cardiovasc Res, 2011, 92(3): 504-513.
  • 5Yang D, Luo Z, Ma S, et al. Activation of TRPV1 by dietary capsaicin improves endothelium-dependent vasorelaxation and prevents hypertension [J]. Cell Metab, 2010, 12 (2): 130 - 141.
  • 6Huang W, Rubinstein J, Prieto A R, et al. Transient recep- tor potential vanilloid gene deletion exacerbates inflammation and atypical cardiac remodeling after myocardial infarction [J]. Hypertension, 2009, 53(2): 243-250.
  • 7Xu X, Wang P, Zhao Z, et al. Activation of transient recep- tor potential vanilloid 1 by dietary capsaicin delays the onset of stroke in stroke-prone spontaneously hypertensive rats [ J ]. Stroke, 2011,42(11) : 3245 -3251.
  • 8Savoia C, Burger D, Nishigaki N, et al. Angiotensin Ⅱ and the vascular phenotype in hypertension [ J ]. Expert Rev Mol Med, 2011, 13: e11.
  • 9Zhang L, Xie P, Wang J, et al. Impaired peroxisome prolifera- tor-activated receptor-gamma contributes to phenotypic modula- tion of vascular smooth muscle cells during hypertension [ J 1. J Biol Chem, 2010, 285(18) : 13666-13677.
  • 10Bonta P I, Pols T W, van-Tiel C M, et al. Nuclear receptor Nurrl is expressed in and is associated with human resteno- sis and inhibits vascular lesion formation in mice involving inhibition of smooth muscle cell proliferation and inflamma- tion [ J]. Circulation, 2010, 121(18) : 2023 - 2032.

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中国细胞生物学学报
2016年 第8期

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