运动对MSCs向成骨细胞分化相关信号通路的影响

The Effects of Sports on the Signaling Pathways Associated with MSCs' Differentiation into Osteoblast

该文综述了运动对骨代谢的影响,包括骨组织受到的应力、激素的分泌及营养等方面的作用。该文重点从TGF-β/BMPs(transforming growth factor beta/bone morphogenetic protein)、MAPK(mitogen-activated protein kinase)和Wnt信号通路等方面,综述了运动对间充质干细胞(mesenchymal stem cells,MSCs)向成骨细胞分化的影响,提出了运动强度、时间及肌纤维类型对MSCs向成骨细胞分化的重要作用。同时,提出运动后的疲劳恢复对MSCs向成骨细胞分化的作用十分重要,为运动训练对骨代谢影响提供理论参考。

Sports can affect the bone metabolism form the aspects of physical force, hormone and nutrition. This article was mainly stating that how sports affect the signal pathways of mesenchymal stem cells （MSCs） differentiation into osteoblast from transforming growth factor beta/bone morphogenetic protein （TGF-β/BMPs）, Wnt, mitogen-activated protein kinase （MAPK）. It was found that sports intensity, time and types of muscles are important in the differentiation of MSCs to osteoblast. And more, rest after sports also play an important role in the differentiation of MSCs to osteoblast. This review provided theory reference for how sports affect bone metabolism.