太极拳运动对慢性荨麻疹患者外周血IFN-γ和IL-4水平的影响

The Influences of Tai Ji Quan Exercise on the Levels of IFN-γ and IL-4 in Peripheral Blood of Patients with Chronic Urticaria

目的研究太极拳运动对慢性荨麻疹的临床疗效及对患者外周血干扰素(IFN)-γ和白介素(IL)-4的影响。方法 90例慢性荨麻疹患者被分为对照组,太极拳组,跑步组。对照组每日给予盐酸西替利嗪片10mg口服,共90天。太极拳组常规治疗同对照组,并进行太极拳套路锻炼。跑步组常规治疗同对照组,并进行中等强度的跑步运动锻炼。采用双抗体夹心法测定患者治疗前、后血清中IFN-γ和IL-4的含量。结果治疗90天后,太极拳组有效率85.71%,跑步组有效率62.07%,对照组有效率57.69%。治疗前,太极拳组患者血清IL-4水平显著高于对照组血清IL-4水平(P<0.05),太极拳组患者血清IFN-γ水平显著低于对照组血清IFN-γ水平(P<0.05)。治疗结束后,太极拳组患者血清IL-4水平显著低于其治疗前血清IL-4水平(P<0.05),但仍高于对照组血清IL-4水平(P<0.05),而且太极拳组患者血清IFN-γ水平显著高于治疗前血清IFN-γ水平(P<0.05),但仍显著低于对照组(P<0.05)。跑步组患者与对照组人群治疗前、后血清中IFN-γ和IL-4水平差异均无统计学意义(P均>0.05)。结论太极拳运动可以调控慢性荨麻疹患者体内细胞因子IFN-γ和IL-4水平,重建T辅助细胞亚群(Th1/Th2)平衡。太极拳运动是治疗慢性荨麻疹较为理想的运动方式。

Objective To study the influences of Tai Ji Quan exercise on the levels of IFN-γ/ and IL-4 in peripheral blood of patients with chronic urticaria. Methods Ninety cases of chronic urticaria were randomly divided into control group, Tai Ji Quan group, running group. Patients in control group took citirizine tablet 10mg once a day. Patients in Tai Ji Quan group took Tai Ji Quan exercise besides taking citirizine tablet 10mg once a day. Patients in running group took running exercise besides taking citirizine tablet 10mg once a day. The serum levels of IFN-γ and IL-4 from both patients and healthy controls were measured by ELISA before and after the treatment. Results In comparison with healthy controls, The serum level of IL-4 was significantly higher and the serum level of IFN-3, was significantly lower in patients with chronic urticaria in Tai Ji Quan group, running group and control group before the treatment （P 〈 0. 05 ）. After treatment, the serum level of IL-4 in Tai Ji Quan group was significantly decreased（ P 〈 0. 05 ）, but still significantly higher than in healthy controls （P 〈 0. 05 ）. Meanwhile, the serum level of IFN-γ in Tai Ji Quan group was significantly increased after treatment, but still significantly lower than in healthy controls （P 〈 0. 05）. The concentrations of IL-4 and IFN-γ, in running group and control group had no significant difference before and after treatment. Conclusion Tai Ji Quan Exercise can regulate the serum levels of cytokine IL-4 and IFN-γ in patients with chronic urticaria and rehabilitate the balance of Th1/Th2, Tai Ji Quan Exercise benefits chronic urticaria.