安列克在HIFU治疗子宫肌瘤中的作用探讨

Effects of carboprost tromethamine on HIFU ablation of uterine fibroid

目的探讨宫颈注射安列克能否提高HIFU治疗子宫肌瘤的效率。方法选择该院2014年12月至2015年9月期间140例单发子宫肌瘤患者随机分为安列克组和对照组。安列克组HIFU术前宫颈注射安列克250μg,对照组注射等量生理盐水;在达到治疗标准后,比较两组患者HIFU治疗的辐照时间、治疗时间、团状强回声的出现率及术后并发症情况。结果安列克组的肌瘤平均体积(71.46±72.43)cm3,在显著大于对照组(35.84±39.27)cm3的情况下,两组的平均辐照时间分别为(715.4±478.1)s和(745.0±544.8)s,差异无统计学意义(P>0.05),但安列克组的患者在HIFU治疗中的团状强回声的出现率(70.37%)显著高于对照组(54.10%),得出安列克组消融单位体积肌瘤所用的平均时间(19.15±23.31)s/cm3,显著低于对照组(40.22±38.27)s/cm3,提高了治疗效率;而除了仅有暂时性的安列克药物不良反应外,两组均无严重的并发症出现。结论安列克增加了子宫肌瘤HIFU术中团状强回声的出现率,能安全有效地提高HIFU治疗的效率。

Objective To explore whether carboprost tromethamine can improve the efficiency on HIFU ablation of utreme fibroid. Methods A total of 140 patients with solitary uterine fibroid from December 2014 to September 2015 in the Fourth People＇s Hospital of Zigong City were randomly divided into treatment groupo and control group,70 cases in each group. Patients in treatment group were ablated by HIFU after 250 μg carboprost tromethamine was injected into cervi. In control group, the process were the same as those m treatment group was replaced by saline. After up to standard of HIFU treatment, the irradiation time, treatment time,the probability of bolus gray-scale change and adverse reaction were recorded and compared. Results The average volume of utreine fibroid in treatment group（71.46±72.43） cm3 was larger than that in control group（35.84 ± 39.27）cm3 , but the average irradiation time in treatment group and control group were（715.4 ± 478.1） s and（745.0 ± 544.8） s, respectively, there was no significant difference（P〉0.05）. While the probability of bolus gray-scale change in treatment group（70.37%）was significantly higher than control group（54.10 % ）, so the average time of ablation unit volume myoma in treatment group（19.15±23.31）s/cm3 was significantly lower than in control group（40.22±38.27）s/cm3. In addition to drug adverse reaction in carboprost tromethamine only temporary,no serious complication occurred in two groups. Conclusion carboprost tromethamine can increase the ratio of bolus grayscale change and Improve efficiency, safely and efficiently in HIFU treatment.