广东珠海地区健康体检者血浆总同型半胱氨酸水平的分布特点

The characteristic of total plasma total homocysteine level distribution in population of Zhaihai area

目的 观察广东珠海地区体检人群血浆总同型半胱氨酸（tHcy）水平及其分布特点,分析与血浆tHcy相关的因素。方法 选取2013年1~12月在广东省珠海市中山大学附属第五医院检测血浆tHcy及相关生化指标的健康体检者1 136例,对血浆tHcy水平分布特点及与血浆tHcy相关的因素进行统计学分析。结果广东珠海地区人群中血浆tHcy几何均数男性（16.11μmol/L）高于女性（12.92μmol/L,P〈0.01）;如以血浆tHcy〉10.00μmol/L则诊断为高同型半胱氨酸血症（HHcy）,则男性的检出率为97.81%,高于女性的86.67%。血浆tHcy水平随年龄的增长有升高趋势。多重线性回归分析显示性别、年龄和血浆肌酐影响血浆Hcy的水平。结论 广东珠海地区体检人群血浆tHcy水平及HHcy的检出率较高,且随年龄的增长有升高的趋势。性别、年龄和血浆肌酐可以影响血浆tHcy水平。

Objective To describe plasma total homocysteine（tHcy） levels,distribution and its associated factors in population of Zhuhai area. Methods A total of 1 136 population in Zhuhai area for health examination in the Fifth Affiliated Hospital of Sun Yat-sen University from January to December in 2013 were selected. The plasma tHcy of the population were compared and correlations with other risk factors were analyzed. Results The geometric mean of plasma tHcy was higher in males than that in females（16. 11 vmol/L vs. 12. 92μmol/L, P〈0. 01）;the prevalence rate of hyperhomocysteinemia（tHcy〉 10. 00 vmol/L）was 97.81% in males,higher than 86.67% in females,and the plasma tHcy level tended to increase with the growth of the age. The multiple linear regression analysis showed that gender,age and plasma creatinine affected the plasma tHcy level. Conclusion The population in Zhuhai area has high plasma tHcy level and prevalence rate of homocysteinemia. The gender,age and plasma creatinine are influential factors of plasma tHcy level.