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右美托咪定用于全麻联合区域阻滞下小儿腹股沟区手术的效果 被引量:14

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摘要 目的 探讨右美托咪定在小儿腹股沟区手术中的麻醉效果。方法 拟在全麻联合区域神经阻滞下行腹股沟区手术患儿50例,年龄1~5岁,体质量8~24 kg,ASA分级Ⅰ或Ⅱ级,采用随机数字表法将其分为2组各25例,右美托咪定组经10 min静脉泵注右美托咪定0.5μg/kg,之后以0.1μg/(kg·h)的速率持续静脉泵注至缝皮;对照组以同样方式输注等容量生理盐水。2组患儿吸入七氟醚麻醉维持,用1%利多卡因行髂腹股沟神经-髂腹下神经联合阻滞。于右美托咪定给药前(t0)、给药后10 min(t_1)、手术开始即刻(t_2)、手术开始后10 min(t_3)、拔除喉罩即刻(t_4)时点记录患儿MAP和HR;记录手术时间、拔除喉罩时间、苏醒时间和不良事件发生情况。结果 与t0比较,对照组t_1—t_3时点MAP和HR显著降低,t_4时显著升高(P〈0.05);右美托咪定组t1时点MAP和HR显著降低(P均〈0.05),t_2—t_4时点与t0比较差异无统计学意义(P〉0.05)。与对照组比较,右美托咪定组拔除喉罩时间和苏醒时间缩短,辅助呼吸、苏醒期躁动、心动过速和上呼吸道梗阻发生率降低,差异均有统计学意义(P均〈0.05)。结论 右美托咪定可安全用于小儿腹股沟区手术全麻联合区域阻滞麻醉,能有效抑制围术期应激反应,降低患儿麻醉苏醒期躁动发生率。
出处 《现代中西医结合杂志》 CAS 2016年第29期3286-3288,共3页 Modern Journal of Integrated Traditional Chinese and Western Medicine
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参考文献13

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