糖尿病阴虚热盛型患者C反应蛋白的表达水平研究

Level of C Reactive Protein in Patients with Diabetes Mellitus Due to Yin Deficiency and Heat

目的:研究糖尿病阴虚热盛型患者C反应蛋白(CRP)的表达水平。方法:选取本院2015年3月—12月收治的252例糖尿病患者及同期接受的60例糖耐量异常患者为研究对象。采用酶联免疫吸附法(ELISA)对糖尿病患者及糖耐量异常患者CRP进行检测比较。将252例糖尿病患者进行中医辨证分型:阴虚热盛组85例、气阴两虚组49例、阴阳两虚组55例、血瘀脉络组43例、无法分型组20例,比较各亚组CRP,将所得数据进行统计,分析CRP与糖尿病中医证型相关性。结果:T2DM患者CRP、血糖水平均高于糖耐量异常患者,有显著性差异(P<0.05)。T2DM患者各亚组CRP、血糖水平均高于糖耐量异常患者,有显著性差异(P<0.05)。T2DM患者各亚组CRP、血糖水平均高于糖耐量异常患者,有显著性差异(P<0.05)。阴虚热盛型CRP水平低于其他证型,有显著性差异(P<0.05),血糖水平无显著性差异(P>0.05)。T2DM患者各中医证型间CRP水平从低到高依次为:阴虚热盛型<气阴两虚型<阴阳两虚型<血瘀脉络型。无法进行分型的20例患者CRP水平介于阴阳两虚型与血瘀脉络型之间,与两证型比较无显著性差异(P>0.05),与其他证型比较,差异均具有统计学意义(P<0.05)。T2DM中医证型与CRP呈正相关(r=0.412,P=0.015),提示随着T2DM中医证型由阴虚热盛-气阴两虚型-阴阳两虚型-血瘀脉络型进展,CRP相应升高。结论:阴虚热盛型T2DM与CRP密切相关,炎症状态可能是中医阴虚热盛的病理实质之一,分析CRP有助于中医辨证客观化、揭示证的本质。

Objective：To study the expression level of C.reactive protein （CRP） in patients with diabetes due to yin deficiency and heat. Methods ：252 cases of diabetes and 60 cases of imparied glucose tolerance in our hospital from March to December in 2015 were selected as the study subjects. CRP was detected by enzyme linked immunosorbent assay （ELISA） in diabetic patients and imparied glucose tolerance subjects. The 252 cases of diabetes of TCM Syndrome Differentiation Typing： exuberant heat due to yin deficiency and heat （85 cases）, deficiency of both qi and Yin group （49 cases）, yin -yang deficiency （55 cases）, vein blood stasis group 43 cases, cannot type group （20 cases）, each subgroup were compared with CRP, income for statistical data, a- nalysis of CRP and syndrome type of traditional Chinese medicine in diabetes associated. Results ： The levels of CRP and blood glu- cose in T2DM patients were significantly higher than those in imparied glucose tolerence subjects （ P 〈 0.05 ）. CRP and blood glucose levels were significantly higher in T2DM patients than in imparied glucose tolerence subjects, and there were significant differences （P 〈 0.05）. CRP and blood glucose levels were significantly higher in T2DM patients than in imparied glucose toler- ance subjects,and there were significant differences （ P 〈 0. 05 ）. There was a significant difference in the level of CRP （P 〈0. 05 ）, and there was no significant difference in the level of blood glucose （ P 〉 0.05 ）, and there was no significant difference in the blood glucose level （P 〉 0.05 ）. T2DM patients with different syndromes, the CRP levels from low to high as follows ： exuber- ant heat due to yin deficiency and heat type 〈 type of deficiency of both qi and Yin 〈 type of deficiency of both yin - yang defi- ciency 〈 vein blood stasis type. Unable to type 20 cases of patients with CRP levels between deficiency of both yin - yang defi- ciency and vein blood stasis type, with two syndromes of no significant difference （P 〉 0.05 ）, and other syndromes, the difference is statistically significant （ P 〈 0.05 ）. T2DM TCM syndrome type and CRP was positively correlated （ r = 0.412, P = 0. 015 ）, tips with TCM syndrome type of T2DM by exuberant heat due to yin deficiency and heat - deficiency of both qi and Yin - yin - yang deficiency -vein blood stasis and CRP increased. Conclusion：T2DM and CRP are closely related to yin deficiency and heat syn- drome. The inflammatory state may be one of the pathological essence of yin deficiency and heat syndrome. The analysis of CRP can help to objectively and reveal the essence of TCM syndrome differentiation.