常用处方剂量阿司匹林与立普妥对颈动脉斑块的影响

Effect of Commonly Prescribed Doses of Aspirin and Lipitor Carotid Plaque

目的:分析常用处方剂量的阿司匹林与立普妥对颈动脉斑块的影响。方法:收集500例颈动脉斑块患者,给予立普妥20mg/d和拜阿司匹林肠溶片100mg/d治疗,观察治疗后患者双侧颈动脉粥样硬化斑块变化情况。结果:治疗6个月后患者颈动脉斑块较治疗前减小(P<0.001),1年后进一步减少(P<0.001)。治疗前不稳定性斑块数214个(73.5%),治疗后6个月不稳定性斑块数207个(71.1%),下降不明显(P>0.05)。治疗后12个月不稳定性斑块数97个(33.3%),较前明显下降(P<0.001)。结论:常用处方剂量的阿司匹林与立普妥可增强颈动脉斑块的稳定性。

Objective： To analyze commonly prescribed doses of aspirin and lipitor on carotid plaque treatment. Methods： 500 cases of patients with carotid artery plaque were given lipitor （20 mg/d） and aspirin enteric-coated tablets （100mg/d） treatment, and the effect of treatment with bilateral carotid atherosclerotic plaque was observed. Results： Treatment of patients for 6 months significantly reduced carotid artery plaque （P〈0.001）, and further reduce the plaque （P〈0.001） for 1 years. Pre-treatment of unstable plaque in 214 （73.5%） cases for 6 months reduced to 207 （71.1%） cases, with no significance （P〉0.05）;and reduced to 97 （33.3%） after 12 months of treatment （P〈0.001）. Conclusion： The commonly prescribed doses of aspirin and lipitor can enhance the stability of carotid plaque.