B型脑钠肽对合并脓毒症休克的肿瘤患者预后的价值被引量：5

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摘要目的探讨B型脑钠肽(BNP)对合并脓毒症休克肿瘤患者预后评估的价值。方法选取65例脓毒症休克的肿瘤患者,观察其入重症医学科后24 h血浆BNP水平及急性生理学与慢性健康状况系统Ⅱ评分(APACHEⅡ评分)、血乳酸(Lac)、降钙素原(PCT)、白细胞(WBC)等指标;按远期预后(28 d死亡率)将患者分为死亡组(26例)和存活组(39例),比较其相关指标的差异性,并对有差异的指标进行多元logistic回归分析;用受试者工作特征曲线(ROC曲线)评估血浆BNP水平对脓毒症休克患者死亡的预测作用。结果死亡组中BNP、APACHEⅡ评分、Lac及PCT与存活组比较差异有统计学意义(P<0.05);对这四类指标行logistic回归分析提示血浆BNP及Lac是脓毒症休克患者死亡的独立预测因素(P<0.05);采用ROC曲线分析以BNP>1 085 pg/mL为预测死亡界点,其敏感度为95.5%,特异度为76.4%。结论 BNP是评估脓毒症休克肿瘤患者预后的重要指标之一,对患者死亡率有较好的预测价值。

作者杨勇王新朋陈小杰任宏方华王宏志

机构地区北京大学肿瘤医院暨北京市肿瘤防治研究所ICU恶性肿瘤发病机制及转化研究教育部重点实验室

出处《广东医学》 CAS 北大核心 2016年第17期2631-2633,共3页 Guangdong Medical Journal

关键词 B型脑钠肽脓毒症休克乳酸

分类号 R631.4 [医药卫生—外科学]

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