组蛋白去乙酰化酶(HDACs)及其在植物中的作用

Histone Deacetylases and Its Roles in Plants

组蛋白去乙酰化酶(HDACs)是一个在真核生物(包括酵母、哺乳动物和植物)中广泛存在的超基因家族。HDACs与组蛋白乙酰基转移酶(HATs)共同作用来调节组蛋白乙酰化的状态,从而影响染色体的结构和功能,调节基因的转录和细胞的多种功能。目前,人们对植物HDACs的研究逐渐增多,很多HDAC基因在不同植物中得到鉴定和研究。综述了HDACs的分类以及在植物生长发育和胁迫反应中的作用,旨在为进一步研究HDAC在植物中的表观遗传调控机理以及培育抗逆新品种奠定理论基础。

Histone deacetylases （ HDACs ） are a supergene family widely distributed in eukaryotes （ including yeast, mammals and plants ） . HDACs act in concert with histone acetyhransferases （HATs） to regulate the status of histone acetylation, thus affecting the structure and function of the chromosome and regulating the gene transcription and a variety of functions of the cells. The researches on plant HDACs are gradually increasing, and many HDAC genes have been identified and characterized in different plants. This paper reviews the classification and the functions of HDACs in development and stress responses in plant, to provide a theoretical basis for further study of epigenetic regulation mechanism of HDAC in plant and cultivate new varieties of resilience.