5-羟甲基糠醛的生物催化氧化研究进展

Research Progress on Biocatalytic Oxidation of 5-hydroxymethylfurfural

5-羟甲基糠醛HMF是重要的生物基平台化合物,将HMF氧化成呋喃类化合物是生物质转化的重要发展方向。生物催化具有选择性高、反应条件温和,环境友好等优势。近年来生物催化氧化HMF广受关注。从HMF生物转化过程的发现、HMF在微生物的代谢过程以及全细胞转化和酶法催化HMF氧化3个方面对该领域的研究进行综述,并对HMF的生物催化氧化过程发展方向进行展望,以期为绿色高效催化5-羟甲基糠醛制备呋喃类大宗化学品奠定理论基础。

5-hydroxymethylfurfural （ HMF ） is an important bio-based platform chemical. Oxidation of HMF to furan chemicals is a crucial developing orientation of biomass conversion. In recent years, with the advantages of high selectivity, mild reaction conditions, and environment friendly, the biocatalytic oxidation of HMF has attracted extensive attentions. In this paper, we reviewed the discovery of biotransformation process, microbial metabolism, whole-cell biotransformation and the enzymatic catalytic oxidation of HMF. Finally, we provided the development prospect of bio-catalytic oxidation of HMF in the future, aiming at providing the theoretieal foundation for the green and efficient conversion of HMF to furan bulk chemicals.