化湿减肥方对幼年营养性肥胖大鼠血糖代谢的影响

The influence of impuberism nutritional obesity rat's blood glucose metabolism by Huashi Jianfei Fang

目的探讨化湿减肥方对幼年营养性肥胖大鼠体质量、血脂、血糖的影响。方法将60只Wistar雄性大鼠随机分为正常组(15只)和造模组(45只),分别予以基础饲料和高脂饲料喂养,造模7周后,造模组大鼠随机分为模型组、对照组、化湿减肥组,每组15只。正常组和模型组给予蒸馏水,对照组给予L-肉碱,化湿减肥组给予化湿减肥方,每天灌胃1次,连续灌胃8周后,对各组大鼠的体质量、Lee’s指数进行统计分析,并对血清中总胆固醇(TC)、甘油三酯(TG)、血糖(Glu)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)水平进行比较。结果与正常组比较,模型组大鼠体质量和Lee’s指数,TC,TG,Glu,LDL均有所升高,HDL水平明显降低(P<0.05或P<0.01);与模型组比较,对照组和化湿减肥组上述各指标均有不同程度的改善(P<0.05或P<0.01),且化湿减肥组改善程度更为显著(P<0.01)。结论化湿减肥方对幼年营养性肥胖大鼠有明显的减肥及改善糖脂代谢的作用。

Objective To discuss the influence of impuberism nutritional obesity rat＇s weight,blood lipid and blood glucose treated by Huashi Jianfei Fang. Methods 60 Wistar male rats were randomly divided into normal group（ 15） and moulding group（ 45）,which were both fed with basic diet and high-fat diet respectively for 7 weeks.Then rats in moulding group were randomized into model group,control group,losing weight though resolving dampness group with 15 rats in each.Rats in normal group and model group were given distilled water,the control group applied L-carnitine,losing weight though resolving dampness group were treated by Huashi Jianfei Fang.After gavaging once a day continuously for 8 weeks,rats＇ weight and index of Lee＇s in each group was counted and analyzed,and then TC,TG,GLU,HDL,LDL in serum were compared. Results Comparing with the normal group,some figures became higher,like rats＇ weight and Lee＇s index,TC,TG,Glu,and LDL,but HDL was dropped obviously（ P〈0.05 or P〈0.01）; the above-mentioned indexes were obviously ameliorated in the control group as well as losing weight though resolving dampness group than those in the model group（ P〈0.05 or P〈0.01）,especially in losing weight though resolving dampness group（ P〈0.01）.Conclusion Huashi Jianfei Fang can ameliorate impuberism nutritional obesity rat＇s blood glucose metabolism obviously.