摘要
目的探讨玉屏风颗粒联合双歧杆菌三联活菌散对迁延性腹泻患儿细胞免疫功能的影响及疗效。方法将76例迁延性腹泻患儿随机分为中西医组和西医组,中西医组予以玉屏风颗粒联合双歧杆菌三联活菌散治疗,西医组单纯予以双歧杆菌三联活菌散治疗。治疗8周后观察2组的临床疗效及细胞免疫功能的变化,随访6月观察复发情况。结果中西医组临床总有效率明显高于西医组(χ~2=5.21,P<0.05)。2组患儿治疗前血清CD_4^+,CD_8^+水平和CD_4^+/CD_8^+比值比较,差异均无统计意义(P>0.05);与同组治疗前比较,治疗后2组血清CD_4^+水平和CD_4^+/CD_8^+比值均显著上升(P<0.05或P<0.01),且中西医组上升幅度较西医组更为显著(P<0.05);2组患儿治疗前后CD_8^+水平无明显变化(P>0.05)。中西医组复发率明显低于西医组(χ~2=4.93,P<0.05)。结论玉屏风颗粒联合双歧杆菌三联活菌散治疗儿童迁延性腹泻疗效确切,能增强患儿的细胞免疫功能,并可降低复发率。
Objective To discuss therapy effects and cellular immune function's influence of children with persistent diarrhea treated by combination of Yupingfeng Keli and Bifid Triple Viable. Methods 76 cases of children with persistent diarrhea were randomized into integrated traditional Chinese and Western medicine therapy group( ITCMW) and Western medicine therapy group( WM).Children in ITCMW were treated by combination of Yupingfeng Keli and Bifid Triple Viable while WM only Bifid Triple Viable.After treatment for 8 weeks,the change of clinical therapy effects and cellular immune function were observed.With follow-up of 6 months,relapse was observed.Results The clinical total effective rate of children in ITCMW was obvious higher than it in WM( χ^2= 5.21,P〈0.05). Compared the pre-treatment serum of children in two groups,level of CD4^+,CD8^+ and ratio of CD4^+/ CD8^+ had no significant difference( P〈0.05).Comparing the difference before and after treatment of same group,level of CD4^+ and ratio of CD4^+/ CD8^+ of children's serum significantly rose( P〈0.05 or P〈0.01). Those data mentioned-above in ITCMW rose more obviously than those in WM after treatment( P〈0.05); the level of CD8^+ in children of two groups showed no significant change before and after treatment( P〈0.05),and the recurrence rate in ITCMW was obvious lower than it in WM( χ^2= 4.93,P〈0.05).Conclusion Combination of Yupingfeng Keli and Bifid Triple Viable has the positive therapy effects for children with persistent diarrhea by the methods of strengthening cellular immune function and dropping the recurrence rate.
作者
黄淑美
徐华英
HUANG Shumei XU Huaying(Pediatrics Department of Qingtian TCM Hospital, Qingtian, Zhejiang, 323900, China Pediatrics Department of Qingtian People' s Hospital, Qingtian, Zhejiang, 323900, China)
出处
《中医儿科杂志》
2016年第5期45-48,共4页
Journal of Pediatrics of Traditional Chinese Medicine