不同的血浆纤维蛋白原水平与脑梗死的相关性研究

Correlation between Different Plasma Fibrinogen Levels and Cerebral Infarction

目的:探讨不同的血浆纤维蛋白原(Fib)水平对与脑梗死患者的神经功能及再发脑梗死的相关性。方法:急性脑梗死患者160例,根据Fib水平按四分位法分为Q1组(≤4.02 g/L)、Q2组(4.03~5.26 g/L)、Q3组(5.27~6.39 g/L)、Q4组(≥6.40 g/L)4组各40例,分析Fib水平与神经功能及脑梗死再发的相关性。结果:治疗前、治疗15 d后血浆Fib水平与NIHSS评分均呈正相关(r治疗前=0.68,r治疗后=0.51,P<0.05);再发脑梗死29例(18.13%),再发患者随访期间血浆Fib水平异常发生率高达75.86%,高于非再发患者的13.74%,差异有统计学意义(χ2=45.37,P<0.05);随访期间再发患者血浆Fib水平高于非再发患者,比较差异有统计学意义(t=12.77,P<0.05);再发患者随访期血浆Fib水平与再发时间呈负相关(r=-0.622,P<0.05)。结论:Fib水平与脑梗死患者神经功能及再发具有相关性。

Objective： To explore the correlation among different plasma fibrinogen （Fib） levels, neural function and recurrence of patients with cerebral infarction. Methods： A total of 160 cases of patients with acute cerebral infarction were divided into group Q1 （≤4.02 g/L）, Q2 （4.03-5.26 g/L）, Q3 （5.27-6.39 g/L）, Q4 （≥ 6.40 g/L）, 40 cases in each group. The correlation among Fib levels, neural function and recurrence of infarction were analyzed. Results： 15 days after the treatment, the plasma Fib levels and NIHSS score had a positive correlation （before treatment, r=0.68; after treatment, r=0.51, P〈0.05）. Twenty-nine patients （18.13%） experienced new infarcts during the follow-up period. The incidence of abnormal of Fib level in the recurrent patients was 75.86% and it was higher than that in patients with non-recurrence （13.74%, 22=45.37, P〈0.05）. The plasma Fib levels in the recurrence patients was higher than that in the patients with non-recurrence during the follow-up （t=- 12.77, P〈0.05）. In the recurrence patients, the plasma Fib levels showed a negative correlation with recurrence time （r=- 0.622, P〈0.05）. Conclusion： The Fib levels of patients with cerebral infarction is associated with the neural function and recurrences.