卒中后焦虑患者早期白介素-6及皮质醇变化

Changes in Interleukin-6 Levels and Cortisol Fluctuations in Post-stroke Anxiety Patients

目的:探讨白介素-6(IL-6)以及皮质醇水平与卒中后焦虑(PSA)发生的相关性。方法:选取卒中患者132例,在发病后第1周采用ELISA法检测血清IL-6水平和化学发光免疫分析法检测皮质醇波动变化(8:00与16:00)。另选择健康体检者50例为正常对照组,同样检测IL-6及皮质醇水平(8:00)。发病3周后根据是否发生PSA,将卒中患者分为PSA组32例和非PSA组100例。结果:PSA组的IL-6水平与非PSA组及正常对照组相比均升高,差异有统计学意义(P<0.05)。与正常对照组相比,PSA组和非PSA组的皮质醇均升高(P<0.05),PSA组的皮质醇生物学节律消失。结论:IL-6和皮质醇水平检测可能有助于PSA的早期筛查。

Objective： To observe the association of interleukin-6 （IL-6） and cortisol levels with post-stroke anxiety （PSA）. Methods： Total 132 stroke patients and 50 health people （normal control group） were enrolled. The serum of all patients was collected at 8：00 and 16：00 respectively one week after stroke. The serum of the normal control group was collected only at 8：00. The level of IL-6 were analysed by enzyme-linked immunosorbent assay kit, the levels of cortisol were detected by chemiluminescence immtmoassay. On the 3rd week after stroke, the patients were divided to the groups PSA and non-PSA based on the Diagnosis of PSA. Results： The IL-6 level was elevated significantly in the PSA groups as compared with non-PSA group and normal control group respectively （P〈0.05 for both）. The patients in the both PSA group and non-PSA group had significantly elevated morning cortisol levels in comparison with those in the normal control group （P〈0.05）. The biological rhythm of cortisol in the PSA group disappeared. Conclusion： Detection of IL-6 and cortisol may be helpful for PSA diagnosis in the early stage.