摘要
目的:探讨白介素-6(IL-6)以及皮质醇水平与卒中后焦虑(PSA)发生的相关性。方法:选取卒中患者132例,在发病后第1周采用ELISA法检测血清IL-6水平和化学发光免疫分析法检测皮质醇波动变化(8:00与16:00)。另选择健康体检者50例为正常对照组,同样检测IL-6及皮质醇水平(8:00)。发病3周后根据是否发生PSA,将卒中患者分为PSA组32例和非PSA组100例。结果:PSA组的IL-6水平与非PSA组及正常对照组相比均升高,差异有统计学意义(P<0.05)。与正常对照组相比,PSA组和非PSA组的皮质醇均升高(P<0.05),PSA组的皮质醇生物学节律消失。结论:IL-6和皮质醇水平检测可能有助于PSA的早期筛查。
Objective: To observe the association of interleukin-6 (IL-6) and cortisol levels with post-stroke anxiety (PSA). Methods: Total 132 stroke patients and 50 health people (normal control group) were enrolled. The serum of all patients was collected at 8:00 and 16:00 respectively one week after stroke. The serum of the normal control group was collected only at 8:00. The level of IL-6 were analysed by enzyme-linked immunosorbent assay kit, the levels of cortisol were detected by chemiluminescence immtmoassay. On the 3rd week after stroke, the patients were divided to the groups PSA and non-PSA based on the Diagnosis of PSA. Results: The IL-6 level was elevated significantly in the PSA groups as compared with non-PSA group and normal control group respectively (P〈0.05 for both). The patients in the both PSA group and non-PSA group had significantly elevated morning cortisol levels in comparison with those in the normal control group (P〈0.05). The biological rhythm of cortisol in the PSA group disappeared. Conclusion: Detection of IL-6 and cortisol may be helpful for PSA diagnosis in the early stage.
出处
《神经损伤与功能重建》
2016年第5期419-420,423,共3页
Neural Injury and Functional Reconstruction