Livin、XIAP和Caspase-3在胃癌组织的表达及临床意义

EXPRESSIONS AND THEIR CLINICAL SIGNIFICANCE OF LIVIN,XIAP AND CASPASE-3 IN GASTRIC CANCER PATIENTS

目的研究凋亡相关蛋白Livin、XIAP和Caspase-3在胃癌的表达变化,分析其与胃癌发生的相关性。方法 TUNEL染色检测细胞凋亡情况,免疫组化方法检测Livin、XIAP和Caspase-3蛋白表达的变化,分析其与胃癌临床病理特征之间的关系。结果胃癌组织的凋亡指数明显低于正常组织和癌旁组织(P<0.05)。Livin、XIAP蛋白在胃癌组织的表达明显高于正常组织和癌旁组织(P<0.05),而Caspase-3蛋白的表达明显低于正常组织和癌旁组织(P<0.05)。Livin、XIAP和Caspase-3蛋白的表达与胃癌的淋巴转移有关(P<0.05)。结论 Livin、XIAP和Caspase-3与胃癌的发生密切相关,可作为胃癌发展和预后判断的参考指标。

Objective To study the expressions of Livin ,XIAP and Caspase‐3 in gastric cancer patients and to analyze its correlation to gastric cancer .Methods TUNEL staining was used to detect cell apoptosis . Immunohistochemical method was used to detect the expression changes in Livin ,XIAP and Caspase‐3 in gastric cancer patients .The relationship between the clinical pathological features and the expression chan‐ges was analyzed .Results The apoptosis index in gastric cancer tissue was significantly lower than that in normal tissue and cancer adjacent tissues（ P 〈0 .05） .The expressions of Livin and XIAP proteins in gas‐tric cancer tissue were significantly higher than those in the normal tissues and cancer adjacent tissues（ P〈0 .05） .The expressions of Caspase‐3 protein in gastric cancer tissue were significantly lower than the normal tissue and cancer adjacent tissues （ P 〈0 .05） .The expression of Livin ,XIAP and Caspase‐3 pro‐teins were closely related to the lymphatic metastasis（ P 〈0 .05） .Conclusion Livin ,XIAP and Caspase‐3 were closely related to the incidence of gastric cancer and can be used as an index of gastric cancer develop‐ment and prognosis judgment .