消癌平注射液治疗恶性心包积液的临床疗效观察

Study on clinical effect of Xiaoaiping injection in the treatment of malignant pericardial effusion

目的分析并评价消癌平注射液治疗恶性心包积液的临床疗效及不良反应。方法按照随机数表法将我院自2012年4月至2014年8月期间收治的66例恶性心包积液患者分为观察组与对照组各33例,观察组33例患者给予消癌平注射液,通过静脉滴注方式给药,1次/d,两周为1疗程;对照组33例患者第1-7 d与第15-21 d给予氟尿嘧啶（1.0 g/次）,第8-14 d给予顺铂（60 mg/次）或第1-7 d与第15-21 d用顺铂,第8-14 d用氟尿嘧啶,对比分析两组的临床疗效。结果全部66例患者均1次置管成功,通过第1次引流后,心包的压塞症状即被解除。治疗后观察组的治疗有效率为93.94%（31/33）,对照组的有效率为72.73%（24/33）,观察组的近期临床疗效显著优于对照组（P〈0.05）,存在统计学意义。观察组33例患者均无明显的不良反应发生,对照组发生恶心呕吐及白细胞水平降低、脱发现象较为严重,偶见腹泻现象。结论消癌平注射液治疗恶性心包积液具有疗效确切、不良反应轻微的特点,特别适宜晚期恶性肿瘤患者,提倡临床推广应用。

Objective ： To analyze and evaluate clinical curative effect and adverse reaction of the Xiaoaiping injection in treatment of malignant pericardial effusion. Methods ： A total of 66 cases of malignant pericardial effusion of patients treated during 2012 April to 2014 August were divided into the observation group and the control group with 33 cases in each group, the group of 33 patients were given Xiaoaiping injection admnistered by intravenous infusion, 1 times/d, two weeks in 1 course of treatment ; the control group of 33 patients were 1 - 7d and 15 - 21d giving fluorouracil （ 1 g/times）, 8 - 14d given cisplatin （60mg/） or 1 - 7d and 15 - 21d for 8 - 14d with cisplatin, 5-fluorouracil, and the comparative analysis of clinical curative effects in the two groups was made.. Results ： All the 66 patients had catheter success for the first time af- ter the drainage of pericardial tamponade was lifted. After treatment, the effective rate of the observation group was 93.94% （31/33）, and the control group 72. 73% （24/33）. Recent clinical curative effect in observation group was sig- nificantly better than that in the control group （P 〈 0. 05 ）, and there were statistical significance. The 33 cases of patients in the observation group had no adverse reaction, while in the control group obviously, nausea and vomiting occurres and the levels of white blood cells reduced, hair loss was more serious, and there was occasional diarrhea. Conclusion： The treatment effect of Xiaoaiping injection on malignant pericardial effusion is significant, and adverse reactions are mild, which is especially suitable for patients with advanced malignant tumor, and is worth of clinical application.