脑安胶囊对睡眠呼吸暂停综合征患者认知功能的影响

Influences of Nao An Capsule on the cognitive function in patients with sleep apnea syndrome

①目的探讨脑安胶囊对睡眠呼吸暂停综合征患者认知功能障碍的影响。②方法选择2013年9月~2015年5月华北理工大学附属医院呼吸科收治的睡眠呼吸暂停综合征伴认知障碍患者60例，按照随机数字表法分为对照组和观察组，各30例。对照组患者给予常规无创呼吸机辅助通气治疗，观察组患者在常规无创呼吸机辅助通气治疗基础上给予脑安胶囊口服，两组患者均治疗6个月。采用蒙特利尔认知评估量表（Montrealcognitiveassessmentscale，MoCA）比较两组患者治疗前后认知功能的变化，并观察治疗期间脑安胶囊不良反应发生情况。③结果治疗前两组患者认知功能MoCA各项总评分比较，差异无统计学意义（P〉0．05）。治疗后两组患者认知功能MoCA各项总评分均高于治疗前水平，差异有统计学意义（P〈0．05）；与对照组比较，治疗后观察组认知功能MoCA各项评分明显降低，差异有统计学意义（P〈0．05）。④结论脑安胶囊可能在一定程度上改善睡眠呼吸暂停综合征患者的认知功能。

Objective To explore Nao An Capsule on the cognitive function in patients with sleep apnea syndrome.Methods From our hospital selected 60 patients with cognitive dysfunction of sleep apnea syndrome from September 2013 to May 2015 ,they were randomly divided into control group and observation group,30 patients in each group, control group given routine noninvasive ventilator assis- ted ventilation treatment, observation group on the basis of routine noninvasive ventilator assisted ventilation treatment with brain capsule oral treatment, two groups of patients were treated for 6 months. MoCA compared two groups of patients before and after the change of cognitive function, and observed during the treatment of cerebral capsule related adverse reactions occur. Results Cognitive function in patients with the results of two groups before treatment MoCA the total score comparison, no obvious difference, there was no statistically significant difference （ P 〉0.05）,and cognitive func- tion in patients with two groups of MoCA after treatment the total score were higher than the level be- fore treatment, the difference was statistically significant （ P 〈0.05）,compared with control group, The cognitive function MoCA in treatment group were significantly lower, the difference was statisti- cally significant （ P 〈0.05）.Conclusion Nao An Capsule may have a certain extent to improve sleep apnea syndrome cognitive dysfunction in patients.