上皮性卵巢癌组织中核受体共激活因子蛋白表达水平及其与孕激素受体表达的相关性研究

Relationship between expression level of amplified in breast cancer 1 protein in epithelial ovarian cancer tissues and correlation of its level with expression of progesterone receptor

目的观察上皮性卵巢癌组织中核受体共激活因子（AIB1）蛋白表达水平及其与孕激素受体（PR）表达的相关性。方法将我院收治的23例良性卵巢肿瘤患者作为良性组,21例恶性卵巢肿瘤患者作为恶性组,另外选取25例体检志愿者作为健康组。观察3组受试者AIB1蛋白及PR表达情况,并分析其与临床病理特征的关系及两者的相关性。结果与健康组AIB1阳性表达率为8.00%比较,良性组和恶性组AIB1阳性表达率分别30.43%,66.67%,组间比较差异有统计学意义（P〈0.05）;健康组、良性组和恶性组3组PR阳性表达率44.00%,47.83%,47.62%,3组比较差异无统计学意义（P〉0.05）。低分化、Ⅲ~Ⅳ期、淋巴结转移、浆液型卵巢癌上皮性卵巢癌组织中AIB1蛋白阳性表达率分别为70.00%,84.62%,91.67%,85.71%;同时这4种情况的PR阳性表达率分别为60.00%,53.85%,66.67%,57.14%,与高中分化、Ⅰ~Ⅱ期、无淋巴结转移及非浆液型比较,差异均有统计学意义（P〈0.05）。AIB1蛋白表达与PR表达之间无相关性（r=0.002,P〉0.05）。结论 AIB1蛋白表达水平与上皮性卵巢癌组织的关系密切,但和PR表达之间无相关性。

Objective To explore the relationship between expression level of amplified in breast cancer 1（ AIB1） protein in epithelial ovarian cancer tissues and expression of progesterone receptor（ PR）. Methods Twenty- three cases of patients with benign ovarian tumor treated in our hospital were as the benign group,another twenty- one cases of patients with malignant ovarian tumor were as the malignant group,then twenty- five cases of healthy volunteers were selected as the healthy group. The expressions of AIB1 protein and PR in the three groups were observed. The correlations between the expression and clinical pathological characteristics were analysed. Results Compared with those in the healthy group,the positive- expression rates of AIB1 in the benign group and malignant group were 30. 43% and 66. 67%,which were obviously increased（ P 〈 0. 05）. Compared with that in the benign group,the positive- expression rate of AIB1 in the malignant group was 66. 67%,which was obviously increased（ P 〈 0. 05）. The differences in the positive- expression rates of PR among the three groups were not statistically significant with 44. 00%,47. 83%,47. 62%,respectively（ P 〉 0. 05）.The positive- expression rates of AIB1 in tissues with low differentiation,stage Ⅲ to Ⅳ,lymph node metastasis,serous type of epithelial ovarian cancer were 70. 00%,84. 62%,91. 67% and 85. 71%. And the positive- expression rates of PR in that were 60. 00%,53. 85%,66. 67% and 57. 14%,which were obviously lower than those in the tissues with high and moderate differentiation,stageⅠto Ⅱ,non lymph node metastasis and non serous type（ P 〈 0. 05）. There was no correlation between the expressions of AIB1 protein and PR（ r = 0. 002,P 〉 0. 05）. Conclusion The expression level of AIB1 protein is closely related to epithelial ovarian cancer,but there is no correlation with PR expression.