黄芪甲苷对心脏缺血再灌注损伤的保护作用研究现状

Progress in research for protective mechanisms of Astragaloside Ⅳ during cardiac ischemia reperfusion injury

黄芪甲苷为黄芪主要有效成分,其对缺血-再灌注所致的心肌损伤有明显保护作用。本文主要从黄芪甲苷对心肌缺血再灌注损伤后清除氧自由基、减少钙离子超载、调节线粒体通透性转换孔及抗炎等方面综合阐述黄芪甲苷对心肌缺血再灌注损伤保护作用机制进行阐述。

Astragaloside Ⅳ which is the main active ingredient of Astragalus,Astragaloside Ⅳ has protective effection to myocardial injury ischemia and hypoxia,ischemia- reperfusion,this study aimed to discusse scavenging oxygen free group,playing an important role in anti- oxidation; reducing calcium overload, regulating mitochondrial dysfunction and anti- inflammatory effection may reduce infiltration of inflammatory cells,and to describe AstragalosideⅣ cardiac ischemia- reperfusion injury protection mechanism.