脂蛋白相关磷脂酶A2与急性动脉硬化性脑梗死的相关性研究

Correlation between Lipoprotein Associated Phospholipase A2 and Acute Cerebral Infarction in Patients with Acute Cerebral Infarction

目的研究血清脂蛋白相关磷脂酶A2(Lp-PLA2)水平与急性动脉硬化性脑梗死的相关性,为临床诊断及干预治疗提供依据。方法急性脑梗死组91例、对照组51例。研究Lp-PLA2与颈动脉斑块形成及稳定性、急性脑梗死发生、进展与复发、神经功能缺损程度等之间的关系。统计学处理采用SPSS 19.0分析软件进行分析。结果高血清Lp-PLA2水平是急性动脉硬化性脑梗死的独立危险因素。血清Lp-PLA2水平病例组和对照组两组有斑块者的均高于无斑块者(P<0.05),病例组中不稳定斑块组高于稳定组(P=0.004)。血清Lp-PLA2水平复发脑梗死患者明显高于初发脑梗死患者(P<0.05)。血清Lp-PLA2水平与神经功能缺损程度呈正相关(r=0.300,P<0.01)。结论高血清LpPLA2水平是动脉硬化性脑梗死的独立危险因素。血清Lp-PLA2水平升高与颈动脉粥样硬化斑块的形成及不稳定性有关。复发脑梗死组血清Lp-PLA2水平明显高于对照组。Lp-PLA2水平与神经功能缺损程度呈正相关。

Objective To evaluate whether lipoprotein associated phospholipase A2（Lp-PLA2） could be used to provide information on the diagnosis and early intervention of acute atherosclerotic cerebral infarction,through examining the relationship of Lp-PLA2 with acute cerebral infarction.Methods Ninty One and fifty one participants were enrolled.The relationships between Lp-PLA2 and other factors for stroke,the formation and stability of Carotid plaques, the occurence、progress and relapse of acute cerebral infarction,severity of neurological deficits were analyzed.Statistical analysis was done by using SPSS 19 software.Results High serum Lp-PLA2 level was risk factors of acute cerebral infarction.Serum Lp-PLA2 level in the plaque group was significantly higher than that in the non-plaque group in both case and control groups（P〈0.05）.Serum Lp-PLA2 level in the group with unstable plaque was significantly higher than that in the group with stable plaque （P=0.004）.Serum Lp-PLA2 level of patients with recurrent cerebral infarction was significantly higher than that of primary cerebral infarction patients（P〈0.05）. Spearman correlation analysis showed that serum Lp-PLA2 level was positively correlated with the severity of neurological deficits（spearman correlation coefficient：0.300,P〈0.01）.Conclusion High serum Lp-PLA2 level is independent risk factor for cerebral infarction.Serum Lp-PLA2 level in recurrent cerebral infarction group is significantly higher than that of the control group,serving as a predictor of recurrent cerebral infarction.Serum Lp-PLA2 level is positively correlated with the severity of neurological deficits.