蛛网膜下腔出血后迟发性脑缺血研究进展

Research Progress of Delayed Cerebral Ischemia After Subarachnoid Hemorrhage

迟发性脑缺血是蛛网膜下腔出血的主要并发症,是导致患者生存质量下降或直接导致死亡主要的原因,幸存者多数伴有神经功能的障碍。迟发性脑缺血的病理生理机制复杂,目前尚没有一套完整的理论能够很好地阐述蛛网膜下腔出血后迟发性脑缺血的机制。血脑屏障的破坏、微血管痉挛、细胞凋亡、脑自身调节失衡、氧化应激与炎性反应等众多因素均可参与到迟发性脑缺血的形成已经逐渐被人们所接受,同时也为治疗蛛网膜下腔出血后迟发性脑缺血提供一些新的治疗策略。但是蛛网膜下腔出血后迟发性脑缺血的机制及治疗等仍有许多问题并未完全解决,有待于进一步的研究。

Delayed Cerebral Hemorrhage was a major complication of subarachnoid hemorrhage,which lead to the decrease of survival quality of patients or directly lead to death,and the main reason for most survivors is with nerve function obstacle.Physiopathologic mechanism of delayed cerebral hemorrhage was complex,which did not have a complete set of theory well to explain.Blood-brain barrier damage, microvascular spasm,cell apoptosis and its regulation of imbalance,oxidative stress and inflammatory reaction,and many other factors are involved in the formation of delayed cerebral hemorrhage,which had been gradually accepted by people,but also provide for the treatment of delayed cerebral hemorrhage after subarachnoid hemorrhage with some new treatment strategies.however,many problems about delayed cerebral hemorrhage after subarachnoid hemorrhage had not been fully resolved,which need a further investigation.