摘要
抑制素B(inhibin B,INHB)是由α及β(B型)亚单位构成的异源二聚体糖蛋白激素,属于转化生长因子β(transforming growth factor-β,TGFβ)超家族的一员。INHB在男性主要由睾丸支持细胞合成,在女性主要由卵巢的中、小窦卵泡颗粒细胞产生,其主要作用是通过负反馈机制抑制垂体促卵泡生成激素(follicular stimulation hormone,FSH)分泌,进而调节配子发生、发育,与雌雄两性生命活动密切相关。
Inhibin B （INHB）, a member of the transforming growth factor β superfamily （TGFβ）, is a heterodimeric glycoprotein hormone composed of α and β subunit （B-type）. In male, INHB is mainly produced by the sertoli cells of testes. In female, INHB is secreted by the granulosa cells of ovarian middle and small antral follicles. The primary function of INHB is selectively to inhibit the secretion of pituitary follicle-stimulating hormone （FSH） by negative feedback and then regulates the gametogenesis. Hence, there is a significant relationship between INHB and life activity in both sexes.
出处
《生殖与避孕》
CAS
CSCD
北大核心
2016年第9期737-744,共8页
Reproduction and Contraception
基金
2013年全军后勤科研项目
项目号:BBJ13C001
