激光散射法测定红参微粉的粒度分布

Measurement of Particle Size Distribution of Ginseng Powder by Laser Light Scattering Method

目的建立激光散射法测定红参微粉粒径分布的方法。方法采用Malvern Mastersizer 3000E激光粒度分析仪,AERO M型干法进样器进行测定。进样空隙高度：1.5 mm,分散气压：3.5 bar,进样速度：60%,折射率：1.52,样品和背景测量时间：30 s,吸收度：0.1,遮光度：0.5%-5%。结果 5批红参微粉重复性测定结果中,Dv（10）、Dv（50）、Dv（90）的RSD均〈4%,符合中国药典2015年版相关要求。结论激光散射测定法稳定可靠,可用于红参微粉的粒度分布测定。

OBJECTIVE To establish a laser light scattering method for the determination of particle size distribution for ginseng powder. METHODS The Malvern Mastersizer 3000 E and AERO M dry autosampler were used for determination. The conditions of determination were as follows： gap height was 1.5 mm, dispersing pressure was 3.5 bar, feed rate was 60%, the refraction rate was 1.52, the measurement time of background and sample was 30 s, the absorption of 0.01, and the obscuration was 0.5%-5%. RESULTS RSD of Dv（10）, Dv（50） and Dv（90） were all 〈4% in the repeated messurement results of 5 batches of ginseng powder, which were all in line with the requirements of China Pharmacopeia 2015 Edition. CONCLUSION The determination method of laser light scattering method is stable and reliable, and it＇s suitable for the particle size control of ginseng powder.