摘要
目的探讨丙戊酸钠引起高血氨脑病的机制、危险因素以及防治措施,为临床用药提供建议。方法临床药师参与并总结1例丙戊酸钠所致高血氨脑病患者的诊治。结果丙戊酸钠在与苯巴比妥、托吡酯等药物联用时可能会增加高血氨脑病的风险。结论临床上需要避免苯巴比妥等药物和丙戊酸钠的联用,对于有意识状态改变使用丙戊酸钠的患者及时监测血氨。
OBJECTIVE To investigate the mechanism, risk factors and management of valproate-induced hyperammonemic encephalopathy（VHE）, provide suggestions for clinical medication. METHODS Clinical pharmacists had involved the treatment of a case of VHE. RESULTS While valproate was combined with some drugs, such as phenobarbital or topiramate, the risk of high blood ammonia encephalopathy may be enhanced. CONCLUSION It is necessary to avoid the usage of valproate combined with phenobarbital clinically, meanwhile to timely monitor ammonia of the patients who are taking valproate due to the decreased consciousness.
出处
《中国现代应用药学》
CAS
CSCD
2016年第9期1202-1204,共3页
Chinese Journal of Modern Applied Pharmacy
关键词
丙戊酸钠
高血氨脑病
危险因素
valproate
valproate-induced hyperammonemic encephalopathy
risk factors
