疏血通注射液联合外敷小牛血清去蛋白提取物治疗糖尿病足溃疡的临床观察

Clinical observation of diabetic foot ulcer treated with Shuxuetong plus external application of deproteinised ;calf blood serum injection

目的：评价疏血通注射液联合外用小牛血清去蛋白提取物治疗糖尿病足溃疡的临床疗效。方法选择糖尿病足溃疡患者60例，采用随机数字表法分为两组，治疗组30例外用小牛血清血去蛋白提取物联合静脉滴注疏血通注射液；对照组30例给予常规西药治疗。1个月为1个疗程。两组均采用胰岛素控制血糖，抗生素控制感染，足部溃疡局部清创引流、坏死组织清除等治疗。结果治疗组总有效率显著高于对照组（86．7％比60．0％，χ2＝5．455，P ＝0．020）。肉芽组织出现时间[（6．60±1．14）d 比（10．80±2．17）d，t ＝－3．834，P ＝0．008]，创面愈合时间[（23．62±6．14）d 比（35．65±4．45）d，t ＝－4．405，P ＝0．002]较对照组明显缩短，两组治疗后创面面积均明显缩小，但治疗组更明显[（3．48±1．16）cm2比（8．60±2．51）cm2，t ＝－4．143，P ＝0．007]。结论疏血通注射液联合外敷小牛血清去蛋白提取物治疗糖尿病足溃疡疗效优于常规西药治疗。

Objective To evaluate the clinical effect of Shuxuetong plus external application of deproteinised calf blood serum injection on diabetic ulcer foot.Methods 60 patients with diabetic foot ulcer were enrolled：30 cases （treatment group）were randomly assigned to receive deproteinised calf blood serum injection（external use）plus Shuxuetong（iv gtt）,and the other 30 cases （control group）received routine western medicine therapy.One course of treatment lasted one month.In addition,both two groups received insulin to control blood sugar and antibiotics to control infection,with foot ulcer treated with debridement,drainage,and removal of necrotic tissue etc.Results Com-pared with the control group,the effective rate was higher in the treatment group（86.7% vs.60.0%,χ2 =5.455,P =0.020）.The occurrence time of granulation tissue[（6.60 ±1.14）d vs.（10.80 ±2.17）d,t =-3.834,P =0.008] and wound healing time[（23.62 ±6.14）d vs.（35.65 ±4.45）d,t =-4.405,P =0.002]were shorter in the treat-ment group.The wound area in the two groups reduced after treatment,and the wound area in the treatment group reduced significantly[（3.48 ±1.16）cm2 vs.（8.60 ±2.51）cm2 ,t =-4.143,P =0.007].Conclusion As com-pared with the routine therapy with western medicine,the combination therapy of deproteinised calf blood serum injec-tion plus Shuxuetong has better efficacy for diabetic ulcer foot.