循证药学在抗菌药物临床合理应用中的作用

Effects of Evidence-based Pharmacy in Clinical Rational Use of antibiotics

目的:探讨并评价循证药学在抗菌药物临床合理应用中的作用。方法:采用循证药学对抗菌药物的临床应用进行管理,选取2014年(管理前)和2015年(管理后)台山市妇幼保健院(以下简称"我院")门、急诊或住院伴细菌感染患者各247例,比较管理前后患者治疗第3、5、7日的有效率、感染复发率,以及联合用药、细菌学检查或药物敏感性试验、抗菌药物使用情况及其不合理使用情况。结果:治疗第3、5、7日,管理后患者的有效率高于管理前,感染复发率低于管理前;管理后患者的抗菌药物胜率、联合用药率、抗菌药物持续使用时间均优于管理前,细菌学检查率或药物敏感性试验率高于管理前,抗菌药物不合理使用率低于管理前。结论:循证药学可有效规范抗菌药物的合理应用,从而避免医疗资源的浪费,减少药物滥用及药品不良反应等情况的发生,对临床药物治疗具有积极意义。

OBJECTIVE：To explore and evaluate the effects of evidence-based pharmacy in clinical rational use of antibiotics. METHODS ： Evidence-based pharmacy was adopted to manage the clinical use of antibiotics. 247 patients from outpatient, emergency department or hospitalization with bacterial infection were selected from Taishan Maternal and Child Health Hospital（ hereinafter referred to as ＂our hospital＂）, in 2014 （before management） and 2015 （after management）. The effective rate, infection recurrence rate, drug combination, bacteriological examination, drug susceptibility test, use of antibiotics and the irrational use were compared after treatment of 3 d, 5 d and 7 d. RESULTS ： In the treatment of the 3 d, 5 d and 7 d, compared with after treatment, the effective rate was higher than that of before management, and the infection recurrence rate was lower than that of before management. Meanwhile, the use rate of antibiotics, drug combination rate, administration time of antibiotics were better than that of before treatment, and the rate of bacteriological examination and drug susceptibility test were higher than that of before management, and the irrational use rate decreased. CONCLUSIONS： Evidence-based pharmacy can effectively standardize the rational use of antibiotics, which can avoid the waste of medical resources, reduce the occurrence of drug abuse and adverse drug reactions. It is positive significance to the clinical medication treatment.