阿托伐他汀钙片治疗动脉硬化性脑梗死的疗效观察

Observation on Efficacy of Atorvastatin in Treatment of Patients with Atherosclerotic Cerebral Infarction

目的:探讨阿托伐他汀钙片治疗动脉硬化性脑梗死的疗效。方法:选取江西省奉新县人民医院2014年1月—2015年12月收治的181例动脉硬化性脑梗死患者,按随机数字表法分为对照组和观察组。对照组89例患者给予常规治疗,观察组92例患者在对照组常规治疗的基础上给予阿托伐他汀钙片,比较2组患者的疗效,并观察2组患者白细胞介素6(IL-6)、超敏C反应蛋白(hs-CRP)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、膜-中层厚度及梗死面积(IMT)变化情况。结果:观察组患者总有效率为91.30%(84/92),对照组为71.91%(64/89),2组的差异有统计学意义(P<0.05)。治疗后,2组患者IL-6、hs-CRP、TG、TC、LDL-C、HDL-C均较治疗前明显改善,且观察组改善程度明显优于对照组,差异均有统计学意义(P<0.05)。治疗3、6、12个月后,观察组患者IMT较治疗前明显改善,且显著低于对照组治疗后,差异均有统计学意义(P<0.05)。治疗12个月后,观察组患者大面积脑梗死和小面积脑梗死病例数较治疗前显著减少,差异有统计学意义(P<0.05)。结论:阿托伐他汀治疗动脉硬化性脑梗死的效果较好,具有良好的应用价值。

OBJECTIVE： To investigate the efficacy of atorvastatin in treatment of patients with atherosclerotic cerebral infarction. METHODS： 181 patients with atherosclerotic cerebral infarction admitted into Jiangxi Provence Fengxin People＇s Hospital from Jan. 2014 to Dec. 2015 were selected to be divided into observtion group and control group via the random number table. 89 cases in observation group were given conventional therapy,while 92 cases in observation group additionally received atorvastatin based on thr control group. The efficacy of two groups were compared,and the changes of IL-6,hs-CRP,TG,TC,LDL-C,HDL-C,IMT and infarct size of two groups were observed. RESULTS： The total effective rate of observation group was 91. 30%（ 84 /92）,and control group was 71. 91%（ 64 /89）,with statistically significant difference（ P〈0. 05）. After treatment,IL-6,hs-CRP,TG,TC,LDL-C and HDL-C of two groups had been significantly improved,and the observation group was better than that of control group,with statistically significant difference（ P〈0. 05）. After treatment of 3,6,and 12 months,IMT of observation group had been significantly improved compared with before treatment,and significantly lower than that of the control groupin the same period,with statistically significant difference（ P〈0. 05）. After treatment of 12 months,patients in observation group with large area of cerebral infarction and small area of cerebral infarctionsignificantly decreased compared with before treatment,with statistically significant difference（ P〈0. 05）. CONCLUSIONS： The efficacy of atorvastatin in treatment of patients with atherosclerotic cerebral infarction is significant,which has good application value.