甲泼尼龙联合注射用单唾液酸四己糖神经节苷脂钠治疗急性脊髓损伤的疗效及安全性

Efficacy and Safety of Methylprednisolone Combined with Monosialotetrahexosylganglioside Sodium for Injection in Treatment of Acute Spinal Cord Injury

目的:探讨甲泼尼龙联合注射用单唾液酸四己糖神经节苷脂钠治疗急性脊髓损伤的临床疗效及安全性。方法:选取荆州市第二人民医院2015年1—12月收治的88例急性脊髓损伤患者作为研究对象,按随机数字表法分成观察组和对照组各44例,对照组患者给予甲泼尼龙治疗,观察组在对照组治疗的基础上联合注射用单唾液酸四己糖神经节苷脂钠治疗,比较2组的疗效和不良反应发生情况。结果:治疗后,2组患者运动功能和感觉功能均较治疗前明显改善,且观察组改善情况明显优于对照组,差异均有统计学意义(P<0.05)。观察组患者不良反应发生率为9.1%(4/44),对照组为11.4%(5/44),2组的差异无统计学意义(P>0.05)。结论:甲泼尼龙联合注射用注射用单唾液酸四己糖神经节苷脂钠治疗急性脊髓损伤的效果较好,安全性较高。

OBJECTIVE： To probe into the clinical efficacy and safety of methylprednisolone（ MP） combined with monosialotetrahexosylganglioside sodium for injection（ GM-1） in treatment of acute spinal cord injury（ ASCI）. METHODS：88 patients with ASCI admitted into Jingzhou the Second People＇s Hospital from Jan. to Dec. 2015 were selected to be divided into observation group and control group via the random number table,with 44 cases in each. The control group were treated with MP,while the observation group additionally received GM-1 based on the control group. The efficacy and adverse drug reactions were compared between two groups. RESULTS： After treatment,the improvement of motor function and sensory function in two groups had been significantly improved,and observation group was better than control group,with statistically significant difference（ P〈0. 05）. The incidence of adverse drug reactions in observation group was 9. 1%（ 4/44）,and control group was 11. 4%（ 5/44）,the difference was not statistically significant（ P〈0. 05）. CONCLUSIONS：The efficacy of MP combined with GM-1 in treatment of ASCI was significant with high safety.