摘要
目的:探讨中药液外洗治疗念珠菌性包皮龟头炎的效果。方法:选择2015年1—12月收治的180例念珠菌性包皮龟头炎患者,根据就诊顺序分为G1、G2和G3组,每组各60例。G1组患者采用中药液外洗包皮龟头,1次5 min,早晚各1次;G2组患者采用苦参凝胶外用,早晚各1次;G3组患者采用克霉唑乳膏涂抹,早晚各1次,并配合伊曲康唑胶囊200 mg口服,1日1次,3组的疗程均为7 d。疗程结束后立即进行疗效判定,并从包皮龟头处取分泌物进行镜检及真菌培养。结果:治疗后,3组患者临床症状均好转,G1组总有效率明显优于G2、G3组,差异有统计学意义(P<0.05);G1、G3组患者念珠菌转阴率较G2组高,差异有统计学意义(P<0.05);G3组患者不良反应发生率明显高于G1、G2组,差异有统计学意义(P<0.05)。结论:与苦参凝胶、克霉唑外用+伊曲康唑口服比较,中药液外洗治疗念珠菌性包皮龟头炎在改善患者临床症状方面更具有优势,念珠菌转阴率高,且临床不良反应发生率较低。
OBJECTIVE： To probe into the effects of traditional Chinese medicin（ TCM） washing in treatment of candidal balanitis. METHODS： 180 patients with candidal balanitis admitted from Jan. to Dec. 2015 were selected to be divided into G1,G2 and G3 group via the visiting sequence,with 60 cases in each. G1 group were treated with TCM washing in penis,5 minutes each time,twice a day. G2 group were given external Kushen gelatum twice a day,and G3 group received clotrimazole ointment twice a day,combined with itraconazole capsule by oral（ 200 mg,oncea day）. The treatment course was 7 d. The efficacy was observed after treatment, and the secretion from the peniswerecollected for microscopy and fungal culture. RESULTS： After treatment,the clinical symptoms of three groups had been improved,the total effective rate of G1 group was significantly better than that of G2 and G3 group,with statistically significant difference（ P〈0. 05）. The candida negative rate of G1 and G3 group was higher than that of G2 group,with statistically significant difference（ P〈0. 05）. The incidence of adverse drug reactions in G3 group was higher than that of G1 and G2 group,with statistically significant difference（ P〈0. 05）. CONCLUSIONS：Compared with Kushen gelatum,clotrimazole ointment combined with Itraconazole capsule,TCM washing in treatment of candidal balanitis has more significant effects,especially in clinical symptoms,which has high candida negative rateand low incidence of adverse drug reactions.
出处
《中国医院用药评价与分析》
2016年第9期1198-1200,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
