草酸艾司西酞普兰与米氮平治疗抑郁伴焦虑症的疗效比较

Comparison of Efficacy of Escitalopram and Mirtazapine in Treatment of Depression Combined with Anxiety Disorder

目的:探讨草酸艾司西酞普兰和米氮平治疗抑郁伴焦虑症的临床疗效。方法:选取2012年5月—2015年10月上饶市第三人民医院收治的抑郁伴焦虑症患者108例作为研究对象,以随机数字表法分为观察组和对照组各54例。观察组患者给予艾司西酞普兰治疗,对照组患者给予米氮平治疗。观察2组患者的焦虑、抑郁状态、生活质量及不良反应情况。结果:治疗4、8周后,2组患者的焦虑、抑郁状态均明显优于治疗前,差异有统计学意义(P<0.05),但组间比较的差异无统计学意义(P>0.05);观察组患者的生理功能、生理职能、总体健康、活力维度评分明显高于对照组,差异均有统计学意义(P<0.05);观察组患者的不良反应发生率为14.8%(8/54),对照组为16.7%(9/54),2组的差异无统计学意义(P>0.05)。结论:草酸艾司西酞普兰治疗抑郁伴焦虑症,疗效与米氮平相近,能有效提高患者生活质量,安全、有效。

OBJECTIVE： To probe into the clinical efficacy of escitalopram and mirtazapine in treatment of depression combined with anxiety disorder. METHODS： 108 patients with depression combined with anxiety disorder admitted into the Third Peoples Hospital of Shangrao from May 2012 to Oct. 2015 were selected to be divided into observation group and control group via the random number table,with 54 cases in each. The observation group were given mirtazapine,while the control group were treated with escitalopram. The anxiety,depression,life quality and adverse drug reactions of two groups were observed. RESULTS： After treatment of 4 and 8 weeks,the anxiety and depression of two groups were better than that of before treatment,with statistically significant difference（ P〈0. 05）,yet there was no statistical significance between two groups（ P〈0. 05）. The physiological function,physical role,general health and dynamic dimension score in observation group were higher than those of control group,with statistically significant difference（ P〈0. 05）. The incidence of adverse drug reactions of observation group was 14. 8%（ 8 /54）,and control group was 16. 7%（ 9 /54）,the difference was not statistically significant（ P〈0. 05）.CONCLUSIONS： The efficacy of escitalopram and mirtazapine in treatment of depression combined with anxiety disorder is similar,which can effectively improve the life quality of patients with high safety.