51例参麦注射液不良反应报告

Analysis on 51 Cases of Adverse Drug Reaction Reports Induced by Shenmai Injections

目的:了解参麦注射液所致药品不良反应(adverse drug reaction,ADR)的规律和特点。方法:收集2014年3月—2016年3月对新沂市人民医院(以下简称"我院")上报至国家ADR监测中心有关参麦注射液的51例ADR报告,对患者的性别、年龄、累及器官和(或)系统及临床表现、ADR发生时间等进行分析。结果:≥60岁的老年患者ADR发生例数最多(占56.86%)。39例(76.47%)ADR患者累及心血管系统,表现为胸闷、心慌等,其次为呼吸系统、皮肤及其附件损害。用药10 min内ADR发生比例较高(占58.82%)。结论:参麦注射液所致ADR较为常见,其发生与年龄、给药途径等因素有关,临床应注意药物的合理应用,减少ADR的发生。

OBJECTIVE： To investigate the regulations and characteristics of adverse drug reactions（ ADR）induced by Shenmai injections. METHODS： 51 cases of ADR reports reported to the National ADR Monitoring by Xinyi People＇s Hospital（ hereinafter referred to as ＂our hospital ＂） were collected from Mar. 2014 to Mar. 2016.Analysis was conducted on the patients＇ gender,age,involved organs and（ or） systems and clinical manifestations and occurrence time of ADR. RESULTS： The number of cases in elderly patients≥60 years old took the lead（ 56. 86%）.39 cases of ADR patients involved the cardiovascular system damage, mainly performed as chest distress and dismayed,followed by respiratory system and skin and accessories damage. The ratio of ADR occurred within 10 min after administration was relatively high（ 58. 82%）. CONCLUSIONS： ADR induced by Shenmai injections are common,which are related to the factors of age,route of administration. The clinic should attach more importance to the rational application of drugs,and reduce the incidence of ADR.