基于热分析方法的血流及内皮功能检测技术与仪器

Thermal Analysis Methods for Assessing Blood Flow and Endothelial Functions & Device

末梢血流反映了人体的生理状态,可以为人类的健康管理提供有用的信息。血流的热分析方法是近年发展起来的新方法。本文结合笔者在生物传热方面的研究经验,对血流及内皮功能检测的热分析方法进行了综述。首先介绍了血流热分析方法的基本原理,进一步介绍了基于末梢温度及振荡信号检测内皮功能的国内外研究进展,最后分别对超薄型便携式血流传感器,血流-温度信号转换软件以及基于温度信号的内皮功能检测仪器进行了介绍。

Blood microcirculation system is an important part of the cardiovascular system, and its properties reflect human health, namely, physiological features of cardiovascular system among which one is endothelial function. Nowadays together with known optic techniques of blood flow monitoring skin temperature measurements are developed. In this paper, we review recent development of skin temperature monitoring methods for blood flow analysis and present research progress in numerical simulations of bioheat transfer reached by the authors. First the basic principle of thermal analysis method for assessing blood flow is introduced. Furthermore, the advancement for evaluation of endothelial function basing on skin temperature and temperature oscillation is reviewed. Finally, three kinds of innovative instruments are presented, including an ultrathin, soft, skin-conforming sensor for continuous blood flow mapping, blood flow-skin temperature converting software, and an instrument for diagnostics of endothelial dysfunction.