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沉默信息调节因子1信号通路在脑缺血—再灌注损伤中的保护作用 被引量：11

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摘要 沉默信息调节因子1（silent information regulator,SIRT1）是一种烟酰胺腺嘌呤二核苷酸依赖性组蛋白去乙酰化酶,可通过对各种组蛋白和非组蛋白的去乙酰化作用,调控炎性反应、氧化应激、细胞凋亡等多种病理过程和生命活动,对脑缺血-再灌注损伤起着重要的保护作用。
作者 谭凌菁 王金凤 梅志刚
机构地区 三峡大学医学院国家中医药管理局中药药理科研三级实验室
出处 《中国脑血管病杂志》 CAS CSCD 北大核心 2016年第8期442-445,共4页 Chinese Journal of Cerebrovascular Diseases
基金 缺血性心脑疾病转化医学重点实验室开放基金项目(2016xnxg101)
关键词 再灌注损伤 炎性反应 氧化性应激 细胞凋亡 沉默信息调节因子1 综述
分类号 R743.3 [医药卫生—神经病学与精神病学]
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参考文献28

  • 1Hao C, Zhu PX, Yang X, et al. Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma [ J ]. BMC Cancer,2014,14:978.
  • 2Yin J, Tu C, Zhao J, et al. Exogenous hydrogen sulfide protects against global cerebral ischemia/repedusion injury via its anti-oxidative, anti-inflammatory and anti-apoptotic effects in rats [ J ]. Brain Res, 2013,1491 : 188-196.
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  • 5Yi YW, Kang H J, Kim HI, et al. Targeting mutant p53 by a SIRT1 activator YK-3-237 inhibits the proliferation of triple-negative breast cancer cells [ J ]. Oneotarget, 2013,4(7) :984-994.
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二级参考文献12

  • 1Delmas D,Solary E,Latruffe N. Resveratrol,a phyto-chemical inducer of multiple cell death pathways : apopto-sis,autophagy and mitotic catastrophe [ J ]. Curr MedChem, 2011, 18: 1100-1121.
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  • 3Stunkel W, Campbell R M_ Sirtuin 1 (SIRT1 ) The Misun-derstood HDAC [ J ]. J Biomol Screen, 2011,16:1153-1169.
  • 4Wu Y,Li X, Zhu JX,et al. Resveratrol-activated AMPK/SIRT1/ autophagy in cellular models of Parkinson’s disease[J]. Neurosignals, 2011, 19: 163-174.
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  • 6Su J, Zhang T, Wang K, et al. Autophagy activation con-tributes to the neuroprotection of remote Ischemic percon-ditioning against focal cerebral ischemia in rats [ J ] . Neu-rochem Res, 2014, 39:2068-2077.
  • 7Yan W, Zhang H, Bai X, et al. Autophagy activation isinvolved in neuroprotection induced by hyperbaric oxygenpreconditioning against focal cerebral ischemia in rats[ J].Brain Res, 2011,1402: 109-121.
  • 8Ramadori G, Lee CE, Bookout AL, et al. Brain SIRT1 :anatomical distribution and regulation by energy availabili-ty[J]. J Neurosci, 2008, 28: 9989-9996.
  • 9任俊伟,杨琴,范层层,陈娜.白藜芦醇减轻脑缺血再灌注损伤及其机制[J].第三军医大学学报,2010,32(24):2586-2590. 被引量：12
  • 10毕娟娟,何林,余音,郭倩,叶秀峰.自噬在熊果酸诱导的人脐静脉内皮细胞损伤中的作用[J].中国病理生理杂志,2012,28(4):601-607. 被引量：6

共引文献14

同被引文献140

引证文献11

二级引证文献94

中国脑血管病杂志
2016年 第8期

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