长非编码 RNA 在消化系统肿瘤中的研究进展

Long non-coding RNA in digestive system tumors

长非编码 RNA（lncRNA）是一类长度大于200个核苷酸的 RNA 分子，缺乏功能性开放阅读框，无编码蛋白能力。最近，越来越多的研究证据表明 lncRNA 促进了肿瘤的发生发展。lncRNA 表达异常与消化系统肿瘤生长、转移及耐药等密切相关，可作为消化系统肿瘤诊断、治疗及预后判断的分子标志物。

Long noncoding RNA （lncRNA） is a class of RNA molecules that longer than 200 nucleotides.lncRNA is lack of functional open reading frames and has no protein coding ability.Recently, accumulating evidences indicate that lncRNA plays active roles in tumor carcinogenesis and progression.The aberrant expression of lncRNA is significantly correlated with the growth,metastasis,and therapy-resistance of digestive system tumors.Thus,lncRNA may be served as new targets for the diagnosis,treatment,and progno-sis of patients with digestive system tumors.