慢性胃炎炎症程度及活动度影响因素探讨

Factors affecting degree and activity of inflammation in chronic gastritis

目的探讨慢性胃炎(chronic gastritis,CG)炎症程度及活动度的影响因素及其作用程度,以便更好地指导CG的临床防治.方法采用调查问卷、焦虑自评量表、抑郁自评量表、1 3C尿素呼气试验的方法对有上消化道症状并行胃镜及病理检查确诊为CG的患者进行不良饮食习惯、吸烟、饮酒、胃癌家族史、焦虑、抑郁及幽门螺杆菌(Helicobacter pylori,H.pylori)感染等情况的调查,分析影响CG炎症程度及活动度的危险因素及其所起作用程度.结果根据作用程度大小,影响CG炎症程度的因素有:H.pylori感染、饮酒、吸烟、焦虑状态及不良饮食喜好,OR值分别为8.732、3.666、2.812、2.328、1.978.影响C G活动度的因素有:H.pylori感染和不良饮食喜好,OR值分别为6.437、1.891.结论H.pylori感染、饮酒、吸烟、焦虑状态及不良饮食喜好均可不同程度的影响CG的炎症程度,H.pylori感染及不良饮食喜好可同时影响CG的活动度,因此CG的防治应注重健康教育、心理疏导及药物治疗相结合.

AIM To identify the factors affecting the degree and activity of inflammation in chronic gastritis（CG） and their effect extent, in order to guide the clinical prevention and treatment of CG. METHODS The self-rating anxiety scale（SAS）, self-rating depression scale（SDS） and 13 C urea breath test were used to detect indices such as poor diet habits, smoking, drinking, anxiety, depression and Helicobacter pylori（H. pylori） infection in patients who had upper gastrointestinal（GI） symptoms and were diagnosed with CG by gastroscopy. Factors affecting the degree and activity of inflammation in CG were then identifi ed and their effect extent was analyzed. RESULTS Based on the degree of action, the factors that affect the degree of infl ammation in CG were H. pylori infection, drinking, smoking, anxiety and poor diet preferences（OR = 8.732, 3.666, 2.812, 2.328, and 1.978, respectively）. The factors that affect the activity of infl ammation in CG were H. pylori infection and poor diet preferences（OR = 6.437 and 1.891, respectively）. CONCLUSION H. pylori infection, drinking, smoking, anxiety and poor diet preferences have certain impact on degree of inflammation in CG, and poor diet preferences and H. pylori infection can aggravate the inflammatory activity of CG as well. Therefore, the combination of health education, psychological instruction and medication should be adopted in the prevention and treatment of CG.