摘要
A convergent construction of [2,3]-fused indoline tetrahydropyridazines via an I2/tert-butyl hydroperoxide(TBHP) catalyzed three-component dearomative oxidative coupling of indoles, hydrazines and acetophenone was established in moderate to good yields. This protocol provides a new approach for the synthesis of these biologically interesting fused indolines.
A convergent construction of [2,3]-fused indoline tetrahydropyridazines via an I2/tert-butyl hydroperoxide （TBHP） catalyzed three-component dearomative oxidative coupling of indoles, hydrazines and acetophenone was established in moderate to good yields. This protocol provides a new approach for the synthesis of these biologically interesting fused indolines.
基金
supported by the Ministry of Science and Technology(2016YFA0602900)
the National Natural Science Foundation of China(21372224,21232008,21420102003,21521002)
Shandong Province Independent Innovation and Achievements Transformation of Special(2014XGC06001)
the Chinese Academy of Sciences
