分期中医辨证联合西药治疗小儿原发性肾病综合征100例

Staging TCM Syndrome Differentiation combined with Western Medicine in the Treatment of Pediatric Primary Nephrotic Syndrome for 100 Cases

目的观察自拟中药方联合西药治疗小儿原发性肾病综合征的临床疗效,进一步指导临床。方法选取2014年1月—2016年2月收治的小儿原发性肾病综合征患者100例,将患者随机分为2组,观察组和对照组,每组各50例,对照组给予常规的西医治疗,而观察组在对照组的基础上给予自拟中药方口服,观察2组患儿的临床疗效及治疗前后尿蛋白定量、血浆白蛋白及胆固醇指标变化及不良反应发生情况。结果观察组的临床疗效明显优于对照组,差异显著,具有统计学意义(P<0.05),与治疗前相比,两组患儿治疗后尿蛋白定量、血浆白蛋白及胆固醇指标与治疗前相比均有明显变化,但观察组优于对照组差异具有统计学意义(P<0.05),观察组的不良反应发生率明显低于对照组,差异具有统计学意义(P<0.05)。结论自拟中药方联合常规西药治疗小儿原发性肾病综合征疗效确切,值得临床借鉴。

Objective To observe the clinical curative effect of self-made Chinese medicine combined with Western medicine in the treatment of pediatric primary nephrotic syndrome, and further to guide clinical medicine. Methods Selecting 100 cases of pediatric primary nephrotic syndrome patients in our hospital from January 2014 to February 2016, patients were randomly divided into observa-tion group and control group, with 50 cases in each group. The control group was given conventional Western medicine treatment. The observation group was given oral administration of self-made Chinese medicine on the basis of the control group. The clinical effect, uri-nary protein, plasma albumin and cholesterol index changes before and after treatment and adverse reaction incidence of the two groups were observed. Results The clinical curative effect of observation group was significantly better than that of the control group, and the difference had statistical significance（P 〈0.05）. After treatment, the urinary protein, plasma albumin and cholesterol levels of the two groups had changes, but the observation group was better than the control group, and the difference was statistically significant（ P 〈0.05）. The incidence rate of the adverse reactions of the observation group was significantly lower than that of the control group, and the difference was statistically significant（P〈 0.05）. Conclusion The self-made Chinese medicine combined with Western medicine in the treatment of pediatric primary nephrotic syndrome has definite curative effect, and is worthy of clinical reference.