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MTA1在腹壁子宫内膜异位症中的表达及其临床意义

Clinical significance and expression of MTA1 in endometriosis
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摘要 目的探讨MTA1在腹壁子宫内膜异位症中的表达水平及其临床意义。方法收集50例腹壁子宫内膜异位症患者的在位组织、异位组织和正常子宫内膜手术切除标本,常规石蜡包埋后切片,应用免疫组化SP法检测MTA1在不同组织中的表达水平。结果 MTA1阳性表达率在在位内膜中为76.00%,异位内膜中为64.00%,正常内膜中为22.00%。不同组织中的表达存在明显差异(P<0.001),MTA1阳性表达率与不同组织类型有关(P<0.05),与患者年龄、BMI及月经周期无关(P>0.05)。结论 MTA1蛋白在子宫内膜异位症内膜组织中呈高表达,可作为诊断子宫内膜异位症的有用指标。 Objective To explore the expression of metastasis associated gene 1 in ectopic endometrium of endometriosis. Methods In 50 patients with endometriosis, paraffin-embedded sections of eetopie endometrium, eutopic endometrium and normal endometrium were collected, the expression of MTA1 were examined by immunohistochemistry SP method. Results The positive rate of MTA1 in eutopie endometrium of endometriosis and eetopic endometrium was 76% and 64 % respectively, while that in normal tissues was 22%. There was a statistical significance in the expression of MTA1 between normal and abnormal endomelrium (all P〈0.001). Conclusion MTA1 protein is highly expressed in ectopie endometrium of endometriosis, and may be used as a useful indicator to diagnose endometriosis.
作者 李昕 常珩
出处 《新疆医学》 2016年第8期942-944,共3页 Xinjiang Medical Journal
基金 新疆维吾尔自治区自然科学基金面上项目(No:2012211A041)
关键词 子宫内膜异位症 MTA1基因 免疫组织化学 Endometriosis MTA 1 immunohistochemistry
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  • 1黄章骞,高明.子宫内膜异位症术后应用曲普瑞林和孕三烯酮的疗效观察[J].浙江临床医学,2007,9(6):784-784. 被引量:3
  • 2Hsu AL,Sinaii N,Segars J,et al.Relating pelvic pain location to surgical findings of endometriosis[J].Obstet Gynecol,2011,118:223-230.
  • 3Vercellini P,Frontino G,De Giorgi O,et al.Continuous use of an oral contraceptive for endometriosis-associated recurrent dysmenorrhea that does not respond to a cyclic pill regimen[J].Fertil Steril,2003,80:560-563.
  • 4Hull ML,Charnock-Jones DS,Chan CL,et al.Antiangiogenic agents arc effective inhibitors of endometriosis[J].J Clin Endometrinol Metab,2003,88(6):2889-2899.
  • 5Laschke MW,Elitzsch A,Vollmar B,et al.Combined inhibition of vascular endothelial growth factor(VEGF),fibroblast growth factor and platelet-derived growth factor,but not inhibition of VEGF alone,effectively suppresses angiogenesis and vessel maturation in endometriotic lesions[J].Hum Reprod,2006,21(1):262-268.
  • 6Nawa A,Nishimori K,Lin P,et al.Tumor metastasis-associated human MTA1gene:its reduced protein sequence,localization and association with breast cancer cell proliferation using antisence phosphorothioate oligonuleotides[J].J Cell Bio Chem,2000,79(2):202-212.
  • 7Dannenmann C,Shabani N,Friese K,et al.The metastasis-associated gene MTA1is upregulated in advanced ovarian cancer,represses ERbeta,and enhances expression of oncogenic cytokine GRO[J].Cancer Biol Ther,2008,7(9):1460-1467.
  • 8董喆,戴毅,冷金花,周应芳,张震宇,关峥,郎景和.腹腔镜子宫骶神经切断术治疗子宫内膜异位症疼痛的多中心前瞻性对照研究[J].现代妇产科进展,2009,18(12):894-896. 被引量:7
  • 9仝佳丽,郎景和.子宫内膜异位症的在位内膜病变研究进展[J].现代妇产科进展,2010,19(6):465-467. 被引量:71
  • 10袁明,汪雯雯,高玲,栗妍,李天,王世宣.长效GnRHa预防卵巢子宫内膜异位症术后复发的疗效[J].中国妇幼保健,2013,28(30):5052-5055. 被引量:16

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