胃息肉与幽门螺杆菌感染的相关性分析

The study of correlation between gastric polyps and Helicobacter pylori infection

目的对胃息肉与幽门螺杆菌(Hp)感染的关系进行研究,从而早期干预胃息肉的癌变。方法选取2010年8月~2015年6月于我院行胃镜检查者作为研究对象,观察组为160例胃息肉患者,对照组为160例慢性胃炎患者,详细记录观察组的病理类型,并对切片进行苏木精-伊红染色及改良吉姆萨染色法镜检,对照组的黏膜组织进行染色镜检,比较不同类型胃息肉的分布及与黏膜组织学改变的关系、两组Hp感染及强度、不同类型胃息肉Hp感染及强度。结果胃息肉主要分布在胃体和胃底部,增生性息肉多发于胃体和胃底(P<0.05);观察组Hp感染率为57.50%,对照组Hp感染率为50.63%,两组差异有统计学意义(X^2=8.87,P<0.05),其中观察组以中低强度感染为主,对照组则以中高强度感染为主;息肉部位与非息肉部位在不同类型的息肉中Hp感染及其强度无统计学差异(X^2=1.14,P>0.05)。在Hp感染率中,增生性息肉与胃底腺息肉差异有统计学意义(X^2=7.24,P<0.05)。结论与慢性胃炎患者相比,胃息肉的发生与Hp感染无统计学相关,Hp感染与不同息肉部位无关,但息肉类型不同,Hp感染程度和感染率有差异。

Objective To study the relationship between gastric polyps and Helicobacter pylori （Hp）in Akesu area of Xinjiang, so as to do early intervention of gastric polyps of cancer. Methods 160 patients who got gastric prlyps and underwent gastroscopy from August 2010 to June 2015 were selected as observation objects, and other 160 cases of chronic gastritis patients were chosen as control group. The pathological type in the patients of observation group with polyps was recorded, then the hematoxylin eosin staining was completed and the sections were observed through microscopy by the modified Giemsa staining method. The relationship between distribution of different types of gastric polyps and changes of mucosal histology were analyzed. Infection rate and intensity of HP among two groups were compared. HP infection rates and intensity of different types of gastric polyps were compared. Results Gastric polyps were mainly distributed in stomach. Hyperplastic polyps were distributed in stomach and stomach fundus （P 〈：0.05）. The infection rate was 57.5% （92/160） in observation group, and 50.63% （81/160） in control group. There was significant difference between two groups. The middle and low intension were main infection factors in observation group, while the middle and high intension of infection were main factors in control group. There was no significant difference between the infection rate and intensity of Hp in polyp location and non polyp location in different types of polyps （X^-l.14,P〉0.05）, and there was significant difference between hyperplastic polyps and gastric gland polyps. Conclusion Compared with patients with chronic gastritis, there was no significant correlation between gastric polyps and hehcobacter pylori infection, the infection of HP has nothing to do with the location of the polyp, However, the gradient of infection and infection rates are different in different types of polyps.