煤工尘肺合并细菌性肺炎时超敏C反应蛋白的诊断价值

Diagnostic Value of High Sensitive C Reactive Protein in Patients with Coal Worker's Pneumoconiosis Complicated with Bacterial Pneumonia

目的观察煤工尘肺合并细菌性肺炎时,血清C反应蛋白的数值变化,及二者之间的相互关系及临床意义。方法采用回顾性研究收集尘肺合并细菌性肺炎患者病例68例,检测C反应蛋白、白细胞计数、血沉的数值,抗感染治疗后再次测定上述指标,进行统计分析。结果尘肺合并细菌性肺炎患者治疗前C反应蛋白为(38.45±21.56)mg/L,C反应蛋白阳性率与WBC、血沉阳性率相比,差异有统计学意义(P<0.05)。尘肺组C反应蛋白值治疗后明显降低,与治疗前比较,差异有统计学意义(P<0.01)。结论抗感染治疗过程中,血C反应蛋白监测对于尘肺患者的诊断及抗感染治疗疗效提供了可靠且有力的帮助。

Objective To observe the changes of serum C reactive protein in patients with coal worker＇s pneumoconiosis complicated with bacterial pneumonia, and to study the relationship between them and the clinical significance. Methods Data of 68 eases of pneumoconiesis complicated with Bacterial pneumonia were retrospectively studied. The changes of C reactive protein in 43 patients with viral pneumonia were compared before and after full anti infection. Pneumoconiosis group detection of C reactive protein, leukocyte count, erythrocyte sedimentation rate （ESR） and anti infection treatment were measured again and statistics analyzed. Results The C reactive protein in the pneumoconiosis group was （38.45 ＋ 21.56）rag/L, the pneumoconiosis group C reaction protein positive rate was compared with WBC positive rate and erythrocyte sedimentation rate, the difference was statistically significant （P 〈0.05）. The value of C reactive protein in pneumoconiosis group was significantly lower than that of before treatment, and the difference was statistically significant （P〈 0.01）. Conclusion In the course of anti infection treatment, blood C reactive protein monitoring provides a reliable and powerful help for the diagnosis and anti infection treatment of pneumoconiosis patients.