肺功能改变与重症支原体肺炎患儿远期预后的相关性研究

The study of relationship between pulmonary function changes and long-term prognosis in children with severe mycoplasma pneumonia

目的 探讨肺功能与重症支原体肺炎患儿远期预后的相关性,为此类患儿的诊断和治疗提供依据。方法以重症支原体肺炎患儿150例为观察组,门诊体检的健康儿童150例为对照组。观察组治疗周期为7 d。比较两组肺功能相关指标及治疗前后观察组肺功能相关指标的变化。分析观察组治疗前的肺功能指标与其临床远期预后（出院后9-12个月）评分的相关性。结果 与对照组相比,治疗前观察组的潮气量（Vt/kg）、达峰时间比、达峰容积比显著降低,差异均具有统计学意义（P〈0.05）;与治疗前比较,治疗后观察组的潮气量（Vt/kg）、达峰时间比、达峰容积比显著升高,差异均具有统计学意义（P〈0.05）;潮气量（Vt/kg）、达峰时间比、达峰容积比与重症支原体肺炎患儿的临床预后呈显著的负相关。结论 潮气量、达峰时间比、达峰容积比等肺功能指标在重症支原体肺炎患儿中显著降低,其水平与患儿的预后显著负相关,可用于重症支原体肺炎患儿病情轻重远期预后的评估。

Objective To study the long - term prognosis of patients with severe mycoplasma pneumonia, and to provide evidence for the diagnosis and treatment of this kind of children. Methods 150 cases of children with severe mycoplasma pneumonia in our hospital were selected as the observation group, 150 cases of healthy children as control group. Treatment period was 7 days. Pulmonary function related indexes of all the patients before and after treatment in the observation group. The changes of lung function related indexes were compared before and after treatment in the observation group. To analyze the correlation between the lung function indexes and the clinical prognostic score of the observation group before treatment. Results Compared with the control group, the tidal volume （VT/kg） , time to peak ratio and peak volume ratio in observation group before treatment decreased significantly with statistical significance （ P 〈 0 .0 5 ） . Compared with before treatment, the tidal volume （VT/kg） , time to peak ratio and peak volume ratio after treatment in observation group was significantly increased, the difference is statistically significant （ P 〈 0. 05） . Tidal volume （VT/kg） , peak time ratio, peak volume and clinical outcomes of children with severe mycoplasma pneu-monia showed a significant negative correlation. Conclusion Tidal volume, peak time than peak volume ratio significantly decreased lung function in children with severe mycoplasma pneumonia. The level and the prognosis of children with significant negative correlation. It can be used for the assessment of prognosis and severity of severe mycoplasma pneumonia.