腹腔镜手术联合米非司酮治疗子宫内膜异位症的临床疗效观察

Clinical efficacy and safety of laparoscopic surgery combined with mifepristone in treatment of endometriosis

目的探究腹腔镜手术联合米非司酮治疗子宫内膜异位症的临床疗效及安全性。方法 2013—2015年165例子宫内膜异位症患者,随机分为试验组(85例)和对照组(80例)。试验组腹腔镜手术治疗后服用米非司酮,对照组单纯腹腔镜手术治疗。观察患者治疗效果、月经恢复时间、排卵恢复时间以及不良反应。结果试验组和对照组有效率分别为81.2%和65.0%,试验组疗效显著优于对照组(P<0.05)。试验组治疗后月经和排卵恢复时间均显著短于对照组(P<0.05)。试验组和对照组不良事件的总体发生率分别为15.3%和3.8%,但试验组症状轻。结论腹腔镜手术联合米非司酮能有效治疗子宫内膜异位症且安全性较高,值得在临床上推广。

Objective To explore clinical efficacy and safety of laparoscopic surgery combined with mifepristone in treatment of endometriosis. Methods One hundred and sixty-five patients with endometriosis were collected during 2013 to 2015 and randomly divided into two groups including experimental group（ 85 participants） and control group（ 80 participants）. Patients in control group were treated with laparoscopic surgery. Patients in experimental group were treated with laparoscopic surgery combined with mifepristone. Several indicators regarding curative effect,recovery time of menstruation,recovery time of ovulation and occurrence of adverse events were observed after treatment. Results Curative effect rate in experimental and control group were 81. 2% and65. 0%,respectively. Curative effect in experimental group was significant better than that in control group（ P〈0. 05）. Both of recovery time of menstruation and ovulation in experimental group were substantially shorted than that in control group（ P〈0. 05）. Overall incidence of adverse events in experimental and control group were 15. 3% and 3. 8% respectively,but symptoms of these events in experimental group were mild. Conclusion Therapy of laparoscopic surgery combined with mifepristone in treatment of endometriosis is effective and safe and worth popularizing and applying on clinic.