N末端脑钠肽对院内心搏骤停预后的影响

Prognostic value of NT-pro BNP in patients with in-hospital cardiac arrest

目的评估N末端脑钠肽(NT-pro brain natriuretic peptide,NT-pro BNP)对院内心搏骤停患者预后的影响。方法回顾2011年5月至2016年4月福建省立医院62例院内心搏骤停患者临床资料,以入选患者NT-pro BNP 25百分位数、中位数、75百分位数为界分为四组,比较组间自主循环恢复(restoration of spontaneous circulation,ROSC)率、出院存活率及出院神经功能良好率。结果 NT-pro BNP与自主循环恢复(ROSC)率(R=-0.339,P=0.007)、出院存活率(R=-0.270,P=0.034)及出院神经功能良好率(R=-0.304,P=0.016)呈负相关。结论 NT-pro BNP增高与ROSC率、出院存活率及出院神经功能良好率下降相关,可作为评估院内心搏骤停预后的指标。

Objective The aim of the study is to evaluate the prognostic value of NT-pro BNP in patients with in-hospital cardiac arrest. Method The clinical data of 62 in-hospital cardiac arrest patients of Fujian Provincial Hospital from May 2011 to April 2016 were analyzed retrospectively. The patients were divided into four groups according to quartiles of the NT-pro BNP concentration. The rates of restoration of spontaneous circulation ROSC ,survival to hospital discharge and discharge with favorable neurological outcome were compared among groups. Result The rates of ROSC（R=-0.339,P=0.007）, survival to hospital discharge （R=-0.270,P=0.034） and discharge with favorable neurological outcome（R=-0.304,P=0.016） decreased in a stepwise fashion across the increasing quartiles of NT-pro BNP concentration. Conclusion Increased NT-pro BNP concentration is associated with decreased rates of ROSC, survival to hospital discharge and discharge with favorable neurological outcome.