吸入布地奈德对哮喘儿童血清IL-18水平的影响被引量：3

导出

摘要目的：观察支气管哮喘儿童血清白细胞介素18（ IL-18）的变化以及吸入布地奈德对其的影响。方法选取2014年5月至2015年5月本院诊断为支气管哮喘的患儿68例作为研究对象，其中40例患儿接受布地奈德雾化吸入治疗3个月为治疗组，其余28例未予以激素治疗患儿为常规治疗组。同时选取同时期同年龄组健康体检儿童60例为空白对照组，治疗组以布地奈德雾化吸入治疗3个月，分别测定各组患儿血清IL-18水平并比较其变化。结果哮喘患儿外周血血清IL-18水平显著高于健康对照组患儿（P〈0．05），治疗组患儿经过3个月的布地奈德雾化吸入治疗，其外周血IL-18水平较常规治疗组显著降低，但是仍显著高于对照组（P〈0．05）。结论哮喘患儿血清IL-18水平升高，吸入布地奈德可降低IL-18水平。提示IL-18是哮喘临床疗效的有效评价指标。

作者赵莉刘凯陈凡王丽君欧良红

机构地区辽河油田总医院儿科

出处《国际儿科学杂志》 2016年第9期734-735,共2页 International Journal of Pediatrics

关键词布地奈德哮喘 IL-18

分类号 R725.6 [医药卫生—儿科]

引文网络
相关文献

参考文献8

1FajtML,WenzelSE.Biologic therapy in asthma:entering the new age of personalized medicine[J].J Asthma,2014,51(7):669-676.DOI:10.3109/02770903.2014.910221.
2UshioS,NambaM,OkuraT,et al.Cloning of the cDNA for human IFN-gamma-inducing factor,expression in Escherichia coli,and studies on the biologic activities of the protein[J].J Immunol,1996,156(11):4274-4279.
3Rovina1N,DimaE,BakakosP,et al.Implication of IL-18 in chronic inflammation of severe refractory asthma[J].Clin Transl Allergy,2015,5(Suppl 2)):10.DOI:10.1186/2045-7022-5-S2-O10.
4陈谱,何韶衡,陈穗.小儿哮喘及肺炎血浆白介素-18、-16、-4及IFN-γ水平的相关性研究及临床意义[J].中国小儿急救医学,2006,13(2):112-114. 被引量：7
5儿童支气管哮喘诊断与防治指南[J].中华儿科杂志,2008,46(10):745-753. 被引量：2513
6WildJS,SigounasA,SurN,et al.IFN-gamma-inducing factor(IL-18)increases allergic sensitization,serum IgE,Th2 cytokines,and airway eosinophilia in a mouse model of allergic asthma[J].J Immunol,2000,164(5):2701-2710.
7SawadaM,KawayamaT,ImaokaH,et al.IL-18 induces airway hyperresponsiveness and pulmonary inflammation via CD4+ T cell and IL-13[J].PLoS One,2013,8(1):e54623.DOI:10.1371/journal.pone.0054623.
8HossnyEM,El-SayedSS,El-HadidiES,et al.Serum interleukin-18 expression in children with bronchial asthma[J].World Allergy Organ J,2009,2(5):63-68.DOI:10.1097/WOX.0b013e3181a33649.

二级参考文献11

1胡亚美江载芳.诸福棠实用儿科学[M](第7版)[M].北京:人民卫生出版社,2002.1199-1201.
2Micallef MJ,Ohtsuki T,Kohnok,et al.IFN-γ-inducin factor enhances T helper l cytokine production[J].Eur J Immunol,1996,26:1647.
3Nakanish K,Yoshimoto T,Tsutsui H,et al.Interleukin-18 is a unique cytokine that stimulates both TH1 and TH2 responses depending on its cytokine milieu[J].Cytokine Growth Factor Rev,2001,12(1):53-72.
4Okamoto M,Kato S,Oizumi K,et al.Interleukin 18 (IL-18) in synergy with IL-2 induces lethal lung injury in mice:a potential role for cytokines,chemokines,and natural killer cells in the pathogenesis of interstitial pneumonia[J].Blood,2002,99 (4):1289-1298.
5Tanaka H,Narita M,Teramoto S,et al.Role of interleukin-18and T-helper type 1 cytokines in the development of Mycoplasma pneumoniae pneumonia in adults[J].Chest,2002,121 (5):1493-1497.
6Conti P,Kempuraj D,Kandere K,et al.Interleukin-16 network in inflammation and allergy[J].Allergy Asthma Proc,2002,23(2):103-108.
7Martti L,Ingemar Q,Gerdt CR,et al.Increased levels of interleukin-16 in the airways of tobacco smokeis:relationship with peripheral blood T lymphocytes[J].Thorax,1999,54:911-916.
8Taha RA,Laberge S,Hamid Q,et al.Increased expression of the chemoattractant cytokines eotaxin,monocyte chemotactic protein4,and interleukin-16 in induced sputum in asthmatic patients[J].Chest,2001,120(2):595-601.
9Krug N,Cruikshank WW,Tschernig T,et al.Interleukin 16 and T-cell chemoattractant activity in bronchoalveolar lavage 24 hours after allergen challenge in asthma[J].Am J Respir Crit Care Med,2000,162(1):105-111.
10Kalayci O,Saraclar Y,Kilinc K,et al.Serum levels of eosinophilic cationic protein (ECP),myeloperoxidase (MPO),lipid peroxidation products,interleukin (IL)-5 and interferon (IFN)-gamma in children with bronchial asthma at acute asthma attack and remission[J].Turk J Pediatr,2000,42(1):9-16.