抗结核药致儿童肝损害临床观察

Clinical Observation of the Liver Damage Caused by Anti Tuberculosis Drugs in Children

目的：观察抗结核药致儿童肝损害的临床特点、处理措施及预后。方法对本院收治的847例结核病患儿进行回顾性分析。结果肝损害好发于3岁以下、营养不良的患儿；好发于用药后7-15d；常见临床症状为胃肠道反应；有临床症状患儿肝损害更重；肝损害患儿经相应处理后预后均较好。结论对低龄、营养不良的患重症结核等高风险患儿应制定合理抗结核方案，加强肝功监测，并予正确的处理措施。

Objective To observe the clinical characteristics, treatment measures and prognosis of children with liver damage caused by anti tuberculosisdrugs. Methods Retrospective analysis of 847 cases of tuberculosis in our hospital. Results Liver damage occurs in 3 years of age,children with malnutrition and occurs in 7-15 days after treatment;Common clinical symptoms were gastrointestinal reactions. Liver damage in children with clinical symptoms is more severe;The prognosis in children with the corresponding treatment after the liver damage is better. Conclusion For young,malnourished,suffering from severe tuberculosis in high-risk groups should develop a reasonable anti-TB programs, strengthen monitoring of liver function, and to the correct measures to deal with.