Rasmussen脑炎患者临床表现及脑电图特点分析

Analysis of Clinical Features and EEG Characteristics of Rasmussen Encephalitis Patients

目的探讨Rasmussen脑炎(Rasmussen encephalitis,RE)患儿的临床表现和脑电图(EEG)特点。方法回顾性分析8例RE患儿的临床资料。结果本组8例患儿平均发病年龄7岁2月,以反复部分性或全面性癫痫发作起始,均进展为慢性进行性局灶性癫痫持续状态(EPC),伴进行性认知功能障碍、语言功能障碍以及偏瘫。VEEG背景活动为一侧半球慢波活动或一侧半球为主的双侧各导慢波活动;VEEG发作间期大多为一侧半球或一侧半球为主的双侧各导棘波、棘-慢波、多棘-慢波放电。结论 RE系一种具有特征性的临床表现及脑电图变化的癫痫综合征,提高对该病的认识有助于早期诊断治疗。

Objective To investigate the clinical features and electroencephalogram（ EEG） characteristics of Rasmussen encephalitis（ encephalitis Rasmussen,RE） in children. Methods The clinical data of 8 children with RE were analyzed retrospectively. Results 8 cases of children with an average age of 7 years old and two months in this group were with partial or comprehensive epilepsy repeated hair as a start,all of the progress of chronic progressive focal epileptic state（ EPC） ,with progressive cognitive impairment,language dysfunction and hemiplegia. The background activity of VEEG was a slow wave activity in one hemisphere or bilateral various guided slow wave activity based on one side hemisphere. The onset interval of VEEG was mostly bilateral hemisphere or unilateral hemisphere dominated by bilateral spinal spikes,spike slow wave,and multiple spike slow wave discharge. Conclusions RE is a kind of epilepsy syndrome with characteristic clinical manifestation and EEG change. And to improve the understanding of the disease is helpful for the early diagnosis.