神经连接蛋白1与神经突触及认知功能障碍的关系

The relationship of Neuroligin1,synapses and cognitive dysfunction

大脑信息处理及传输过程需要神经突触的参与,而突触间的特殊细胞黏附分子对神经突触的形成、成熟及功能维持具有重要作用。其中神经连接蛋白1(neuroligin1,NL1)是位于兴奋性突触后膜的细胞黏附分子。NL1通过与神经轴突蛋白1(neurexin1,NRXN1)等分子相互作用,参与突触的发生发展,与突触的可塑性及功能相关。NL1敲除或过表达均可损伤学习记忆功能,提示NL1参与认知功能障碍相关的一些神经精神疾病的病理生理机制。因此,研究NL1的作用可进一步完善认知障碍的发生发展机制,并为认知障碍相关性疾病的防治提供新思路。

All information processing and transmission in the brain involves synapses, the synaptic cell adhesion molecules play an important role in the formation, maturation and maintenance of synapses. Neuroliginl （ NL1） is excitatory postsynaptic transmembrane cell adhesion molecules. The interaction between NL1 and other molecules, such as Neurexinl （NRXN1） , involves in the formation, plasticity and function of synapses. NL1 knockout or overexpression displayed impairment in learning and memory, thus suggesting that NL1 participates in the pathophysiology of neuropsychiatric disease with cognitive dysfunction. Therefore, study of NL1 will open up new avenues to understand pathogenesis of cognitive dysfunction, and may provide a novel insight into prevention and treatment of cognitive dysfunction-associated diseases.