期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Notch信号通路在软骨细胞分化过程中的作用 被引量：9

The effect of notch signaling in chondrocytes differentiation
下载PDF
导出
摘要 Notch信号通路是一条在进化上极具保守、影响细胞命运的信号传导途径。该通路对整个软骨形成过程和维持软骨细胞的表型,调控软骨细胞的增殖、成熟、肥大化以及软骨基质代谢平衡等方面均扮演十分重要的角色。文中就Notch信号通路的组成、激活过程及在软骨细胞分化的具体作用等方面进行综述。 Notch signaling is an important evolutionarily conserved pathway involving the fate of cells translation. Additionally, this pathway also plays an important role in cartilage formation and maintenance of chondrocytes phenotype, regulation of the proliferation, maturation and balance of cartilage matrix metabolism. This paper reviews the composition and activation process of notch signaling, and its specific role in cartilage formation.
作者 刘刚 张磊 扶世杰
机构地区 西南医科大学附属中医医院骨关节科 南方医科大学中医药学院
出处 《医学研究生学报》 CAS 北大核心 2016年第10期1111-1115,共5页 Journal of Medical Postgraduates
基金 四川省科技支撑计划项目(2014SZ0185)
关键词 NOTCH信号通路 骨髓间充质细胞 软骨 软骨细胞 Notch signaling Mesenchymal progenitor cell Cartilage cells Cartilage
分类号 R329 [医药卫生—人体解剖和组织胚胎学]
  • 相关文献

参考文献4

二级参考文献70

  • 1Choi J, Chung JH, Kwon GY, et al. Effectiveness of autologous serum as an alternative to fetal bovine serum in adipose-derived stem cell engineering[J]. Cell Tissue Bank, 2013, 14 (3) : 413-422.
  • 2Peter S, Scutt AM, Wright PC, et al. Comparative study of in vitro expansion of bone marrow-derived mesenehymal stem ceils [J]. Biotechnol Lett, 2013, 35(3) :463-469.
  • 3Shi Y, Su J, Roberts AI, et al. How mesenchymal stem cells in- teract with tissue immune responses[J]. Trends Immunol, 2012, 33(3) : 136-143.
  • 4Battiston KG, Cheung JW, Jain D, eta/. Biomaterials in co-culture systems: Towards optimizing tissue integration and cell signaling within scaffolds[J]. Biomaterials, 2014, 35(15) : 4465-4476.
  • 5Dahlin RL, Ni M, Meretoja VV, et al. TGF-133-induced chon- drogenesis in co-cultures of chondrocytes and mesenchymal stem cells on biodegradable scaffolds [ J ]. Biomaterials, 2014, 35 ( 1 ) : 123-132.
  • 6Xiong N, Yang H, Liu L, et al. bFGF promotes the differentia- tion and effectiveness of human bone marrow mesenchymal stem cells in a rotenone model for Parkinson's disease [ J]. Environ Toxicol Pharmacol, 2013, 36(2) : 411-422.
  • 7Schttrch CM, Riether C, Ochsenbein AF. Cytotoxic CD8 ~ T cells stimulate hematopoietic progenitors by promoting cytokine release from bone marrow mesenchymal stromal cells [ J ]. Cell Stem Cell. 2014. 14(4~ ,460-472.
  • 8Miranda JP, Filipe E, Femandes AS, et al. The human umbili- cal cord tissue-derived MSC population UCX ~~) promotes early motogenic effects on keratinocytes and fibroblasts and G-CSF-me- diated mobilization of BM-MSCs when transplanted in vivo [ J ]. Cell Transplant, 2013, 23 (5) : 324-332.
  • 9Lee MW, Kim DS, Yoo KH, et al. Human bone marrow-derived mesenehymal stem cell gene expression patterns vary with culture conditions[J]. Blood Res, 2013, 48(2): 107-114.
  • 10Lee MW, Kim DS, Yoo KH, et al. Ex vivo expansion of bone marrow mesenchymal stem cells using microcarrier beads in a stirred bioreactor[ J]. Blood Res, 2013, 18 (1) : 173-184.

共引文献28

同被引文献100

引证文献9

二级引证文献56

医学研究生学报
2016年 第10期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部